Phenotyping Heterogeneity and Regionality of the Aorta
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorHeinrich-Heine University, Duesseldorf
About this trial
The aorta distributes cardiac stroke volume into the whole body through its finetuned conductance function, that is propagation and modulation of flow pattern. Physicomechanic properties of the aortic wall assure continuous and homogenous blood flow distribution to organs. The physicomechanic properties of the aortic wall are heterotopic: The collagen/elastin ratio doubles in the abdominal aorta as compared to the thoracic aorta. Malfunction of aortic conduction due to large artery stiffening (LAS) leads to premature wave reflection and excess pulsatility which translate into organ damage in low-resistance beds. The regional heterogeneity of aortic physicomechanic properties and their histomorphological substrate leading to altered regional hemodynamics are not well investigated.
Within the PHaRAo population, there is a spectrum of higher and lower risk patients. The aim of this cohort study is to collect prospectively and systematically clinical research data from PHaRAo patients. This cohort study is an open-end observational study to identify master switches in aortic disease
Eligibility criteria
This trial accepts healthy volunteersQualifiers
apparently healthy volunteers
Disqualifiers
< 18 years
Active Medication
Cardiovascular Disease
MRI not possible
Trial population
healthy volunteers, patients with aortic stenosis, patients with aortic aneurysm
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Collection of Clinical Data
Other interventionprospectively and systematically collection of clinical research data from apparently healthy volunteers and patients with aortic stenosis and aneurysms
Treatment groups
300 Participants
are divided into 3 treatment groupsGroup A: healthy volunteers1 intervention
Group B: patients with aortic stenosis1 intervention
Group C: patients with aortic aneurysms1 intervention
Trial outcomes
Primary outcomes
1
Progressive accelerated Large Artery Stiffening
measured by CMR
Time frame
5 years2
Development of Aortic Aneurysm
measured by CMR
Time frame
5 years3
Progressive accelerated Large Artery Stiffening
measured by tonometry
Time frame
5 yearsSecondary outcomes
1
Diastolic Dysfunction
measured by CMR
Time frame
5 years2
Diastolic Dysfunction
measured by echocardiography
Time frame
5 years3
Ejection Rate and Ejection Time
measured by CMR
Time frame
5 years4
Ejection Rate and Ejection Time
measured by echocardiography
Time frame
5 yearsSponsors and contacts
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Source ClinicalTrials.gov