Post Extraction Changes After Alveolar Socket Preservation Using Autogenous Dentin Graft (ADG) Combined With Either Albumin Platelet-rich Fibrin (ALB-PRF) or Standard Platelet-rich Fibrin (PRF).

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-60
SponsorKafrelsheikh University

About this trial

The study focuses on the impact of tooth loss on alveolar bone, which shrinks significantly within the first three months. To prevent this, strategies like alveolar ridge preservation are used.

Autogenous dentin, taken from the patient, supports healing and bone regrowth. Platelet-rich fibrin (PRF), made from the patient's blood, enhances healing and bone density by releasing growth factors.

A new technique combining L-PRF with albumin creates a stable healing membrane that provides a steady release of growth factors. Overall, these methods improve recovery after tooth extractions and prepare sites for future dental work.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Medically free patients.

Adult patients above 18 Years to 60 Years.

Non-restorable tooth indicated for extraction.

Posterior mandibular teeth.

Disqualifiers

Presence of any systemic disease that could influence the outcome of the therapy.

Presence of any risk factor (smoker, pregnant and lactating patients).

Patients with bone diseases.

Patients with poor oral hygiene.

Trial design

Design model

Parallel

Treatments tested in this trial

  • empty socket

    Other intervention

    Patients will be left socket empty without any graft materials for spontaneous healing process after tooth extraction

  • Autogenous Dentin Graft with Platelet Rich Fibrin

    Procedure/Surgery

    Patients will be inserting autogenous dentin graft and platelet rich fibrin in the socket after extraction.

  • Autogenous Dentin Graft with Albumin Platelet Rich Fibrin

    Procedure/Surgery

    Patients will be inserting autogenous dentin graft and Albumin Platelet Rich Fibrin in the socket after extraction.

Treatment groups

60 Participants
are divided into 3 treatment groups
Group A: empty socketOther 1 intervention
Group B: Autogenous Dentin Graft with Platelet Rich FibrinActive comparator 0 interventions
Group C: Autogenous Dentin Graft with Albumin Platelet Rich FibrinExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Alveolar ridge width (buccolingual).

Will be assessed via Cone-Beam Computed Tomography (CBCT) that Provides a radiographic assessment of the buccolingual width by measuring the distance between buccal and lingual bone walls.

Time frame
at baseline immediately after extraction and after six months
2

Alveolar ridge height (apicocronal)

Will be assessed via Cone-Beam Computed Tomography (CBCT) that Provides a radiographic assessment of the apicocronal height by measuring the ridge height from the top of the alveolar ridge to the upper border of the alveolar canal.

Time frame
at baseline immediately after extraction and after six months
3

Bone density

Will be assessed via Cone-Beam Computed Tomography (CBCT) The measurement helps in assessing the quality of bone directly through Hounsfield units (HU) (between D1 and D5; D1: \> 1250 HU, D2: 850 to 1250 HU, D3: 350 to 850 HU, D4: 150 to 350 HU, D5: \< 150 HU).

Time frame
at baseline immediately after extraction and after six months

Secondary outcomes

1

Pain scores

The patients will report their pain score directly through VAS score (between 0 and 10; 0: no pain, 1: minimal pain, 5: moderate pain, and 10: severe pain).

Time frame
at 24 hours, 3 days, 7 days and 14 days postoperative
2

Patient satisfaction

Will use Surveys/Questionnaires to assess patient satisfaction regarding treatment outcomes and experiences. The patients will report their satisfaction score directly through satisfaction score (between 0 and 4; 0: Very satisfied, 1: Satisfied, 2: Neither satisfied nor dissatisfied, 3: Dissatisfied, 4: Very dissatisfied).

Time frame
at 24 hours, 3 days, 7 days,14 days postoperative and after six months
3

Keratinized tissue width

Will be assessed through probing techniques before and 6 months after surgical intervention. The measurements will be taken at the vertical distance from a line connecting the two neighboring teeth at the CEJs to the free gingival margin (FGM) using a UNC 15 probe (Nordent Manufacturing Inc., IL, USA).

Time frame
at baseline before extraction and after six months

Other outcomes

Sponsors and contacts

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