About this trial
The study focuses on the impact of tooth loss on alveolar bone, which shrinks significantly within the first three months. To prevent this, strategies like alveolar ridge preservation are used.
Autogenous dentin, taken from the patient, supports healing and bone regrowth. Platelet-rich fibrin (PRF), made from the patient's blood, enhances healing and bone density by releasing growth factors.
A new technique combining L-PRF with albumin creates a stable healing membrane that provides a steady release of growth factors. Overall, these methods improve recovery after tooth extractions and prepare sites for future dental work.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Medically free patients.
Adult patients above 18 Years to 60 Years.
Non-restorable tooth indicated for extraction.
Posterior mandibular teeth.
Disqualifiers
Presence of any systemic disease that could influence the outcome of the therapy.
Presence of any risk factor (smoker, pregnant and lactating patients).
Patients with bone diseases.
Patients with poor oral hygiene.
Trial design
Parallel
Treatments tested in this trial
empty socket
Other interventionPatients will be left socket empty without any graft materials for spontaneous healing process after tooth extraction
Autogenous Dentin Graft with Platelet Rich Fibrin
Procedure/SurgeryPatients will be inserting autogenous dentin graft and platelet rich fibrin in the socket after extraction.
Autogenous Dentin Graft with Albumin Platelet Rich Fibrin
Procedure/SurgeryPatients will be inserting autogenous dentin graft and Albumin Platelet Rich Fibrin in the socket after extraction.
Treatment groups
Trial outcomes
Primary outcomes
Alveolar ridge width (buccolingual).
Will be assessed via Cone-Beam Computed Tomography (CBCT) that Provides a radiographic assessment of the buccolingual width by measuring the distance between buccal and lingual bone walls.
Alveolar ridge height (apicocronal)
Will be assessed via Cone-Beam Computed Tomography (CBCT) that Provides a radiographic assessment of the apicocronal height by measuring the ridge height from the top of the alveolar ridge to the upper border of the alveolar canal.
Bone density
Will be assessed via Cone-Beam Computed Tomography (CBCT) The measurement helps in assessing the quality of bone directly through Hounsfield units (HU) (between D1 and D5; D1: \> 1250 HU, D2: 850 to 1250 HU, D3: 350 to 850 HU, D4: 150 to 350 HU, D5: \< 150 HU).
Secondary outcomes
Pain scores
The patients will report their pain score directly through VAS score (between 0 and 10; 0: no pain, 1: minimal pain, 5: moderate pain, and 10: severe pain).
Patient satisfaction
Will use Surveys/Questionnaires to assess patient satisfaction regarding treatment outcomes and experiences. The patients will report their satisfaction score directly through satisfaction score (between 0 and 4; 0: Very satisfied, 1: Satisfied, 2: Neither satisfied nor dissatisfied, 3: Dissatisfied, 4: Very dissatisfied).
Keratinized tissue width
Will be assessed through probing techniques before and 6 months after surgical intervention. The measurements will be taken at the vertical distance from a line connecting the two neighboring teeth at the CEJs to the free gingival margin (FGM) using a UNC 15 probe (Nordent Manufacturing Inc., IL, USA).
Sponsors and contacts
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