About this trial
Post-Intensive Care Syndrome (PICS) refers to long-term cognitive, physical, and psychological impairments that can arise after intensive care treatment. These symptoms may begin within 24 hours of ICU admission and persist for years. Affected patients and their families (PICS-F) face significant burdens, with up to 94% of relatives impacted. Given its high prevalence and socioeconomic impact, this prospective registry study aims to identify risk factors and long-term consequences of PICS and PICS-F.
The study consists of six modules, starting with data collection during ICU stays and continuing with follow-ups at various intervals post-discharge (up to five years). The primary goal is to investigate diagnostic and therapeutic strategies, while secondary objectives include identifying risk factors, determining impairment severity, and exploring biological mechanisms. Standardized questionnaires and biological samples (blood) are used for data collection.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patients with an ICU stay longer than 72 hours will be included
Disqualifiers
Age < 18 years old
Patients who receive end-of-life care at the time of screening
Trial population
Intensive care unit patients
Trial design
Cohort
Prospective
Treatments tested in this trial
Not listed
Trial groups
Trial outcomes
Primary outcomes
Diagnosis of Post-Intensive Care Syndrome (PICS)
Frequency of PICS diagnosis defined as the presence of at least one new or worsened impairment in one of the PICS domains (number/percentage)
Secondary outcomes
Frequency of PICS sub-domains
Frequency of diagnosis of PICS-subdomains
Frailty status
Frailty status assessed by the Clinical Frailty Scale (CFS; score 1-9, higher scores indicate worse frailty).
Post-Intensive Care Syndrome symptoms assessed by the PICS Questionnaire (PICSq)
PICS symptoms assessed by the PICSq (validated questionnaire 0-45 points; higher scores indicate greater impairment).
Physical function assessed by the Barthel Index
Change in activities of daily living, assessed by the Barthel Index (score 0-100; higher scores indicate better function).
Sponsors and contacts
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Medical University of Vienna
Lead sponsor
Charite University, Berlin, Germany
Collaborator
University of Wuerzburg
Collaborator
University Hospital Augsburg
Collaborator