The aim of this study is to explore the relationship between preoperative sleep disorders, melanin-concentrating hormone (MCH), and delayed neurocognitive recovery early after surgery in older adult patients undergoing spinal anesthesia.
Patients of both genders ageing 65 years or above.
ASA grade I to III.
Undergo elective lower limb surgery under spinal anesthesia
Agree to collect one's own CSF and blood samples
Past history of depression,anxiety,delirium and schizophrenia .
Past history of drug dependence.
Past history of dementia,including Alzheimer disease(AD).
Preoperative Montreal Cognitive Assessment (MoCA) score <26.
A total of (50) patients candidate for elective lower limb surgery aged from 65 years of both sexes will be enrolled in this study.
Cohort
Prospective
Not listed
To investigate the impact of preoperative sleep problems as indicators of delayed neurocognitive recovery (DNR) in elderly adults following spinal anesthesia.
By comparison between the two groups
to investigate the predictive power of CSF and plasma MCH levels for delayed neurocognitive recovery (DNR) in older adults after spinal anesthesia
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This trial is not recruiting at the moment. You can still explore other options:
