Postoperative Pain in Photodynamic Therapy Using Curcumin As a Photosensitizer
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-60
SponsorAtaturk University
About this trial
In endodontics, various irrigation solutions are used to achieve antibacterial efficacy within the root canal. The antibacterial effect of curcumin-containing root canal solutions, when combined with photodynamic therapy, has been demonstrated in several studies. However, no research has specifically examined their effect on postoperative pain. The aim of this study is to investigate the impact of using a curcumin solution in combination with photodynamic therapy as the final irrigation solution on postoperative pain.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
healthy patients with aged between 18-60.
Incisor, canine, and premolar teeth that had previously undergone root canal treatment
Incisor, canine, and premolar teeth with a diagnosis of chronic apical abscess or asymptomatic apical periodontitis
teeth with only 1 root canal
Disqualifiers
the presence of a root fracture
teeth with any swelling
ankyloses,
periodontal pockets deeper than 4 mm.
Trial design
Design model
Parallel
Treatments tested in this trial
Curcumin with photodynamic thearpy
Other interventionroot canals will irrigated with final irrigation procedure: curcumin+photodynamic therapy. The teeth will be isolated with a rubber dam, and an access cavity will be created. After root canal preparation, the final irrigation procedure will be performed. Root canal treatments will be completed, and the patients' postoperative pain levels will be recorded using follow-up forms.
Control group
Other interventionroot canals will irrigated with routine root canal final irrigation with NaOCl and EDTA. The teeth will be isolated with a rubber dam, and an access cavity will be created. After root canal preparation, the final irrigation procedure will be performed. Root canal treatments will be completed, and the patients' postoperative pain levels will be recorded using follow-up forms.
Treatment groups
50 Participants
are divided into 2 treatment groupsGroup A: Curcumin with photodynamic therapyExperimental treatment 1 intervention
Group B: control groupActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
postoperative pain levels
postoperative pain levels will be describe using the visual analog scale (VAS). The VAS was classified using the following scale \[15\]: no pain (0); mild pain (1-3); moderate pain (4-6), and severe pain (7-10).
Time frame
one weekSecondary outcomes
1
dependent variables-sex
The patients' genders (female or male) will be recorded, and their relationship with postoperative pain will be statistically analyzed.
Time frame
one week2
dependent variable-age
The patients' ages will be recorded as numbers, and their relationship with postoperative pain will be statistically analyzed.
Time frame
one week3
dependent variables-teeth number
The patients' tooth numbers will be recorded, and their relationship with postoperative pain will be statistically analyzed.
Time frame
one week4
dependent variables-smoking habit
The patients' smoking habits will be recorded as either "yes" or "no," and their relationship with postoperative pain will be statistically analyzed.
Time frame
one weekSponsors and contacts
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Source ClinicalTrials.gov
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