Prospective, observational study to define precipitants and predictors of development of Acute-on-Chronic Liver Failure (ACLF) after surgical interventions, allowing to develop a risk stratification for elective procedures in cirrhotic patients. As well as identifying molecular mechanisms of post-interventional ACLF and thus preparing the ground for development of new therapeutic approaches.
Male or female adult (≥18 years) patient
With or without liver cirrhosis (diagnosed either histologically or by a combination of clinical, laboratory and radiological signs)
Or Non-cirrhotic portal hypertension
Non-pregnant, non-lactating females
Pregnant or lactating females
Patients undergoing surgery as form of palliative cancer therapy
Presence or history of severe extra-hepatic diseases
HIV-positive patients
Patients with and without liver cirrhosis and/or portal hypertension undergoing elective or emergency surgical intervention.
Cohort
Prospective
No Intervention
Other interventionNo Intervention
Episodes of Acute-on-Chronic Liver Failure (ACLF)
Development of ACLF after surgery
1-year mortality
Death after surgery
Episodes of Acute Decompensation
Acute hepatic Decompensation after Surgery
Intestinal Microbiota
Intestinal Microbiota will be assessed in stool samples.
Click on the lead sponsor to view all of their trials.
