The aim of this pilot study is to establish a correlation between perioperative heart rate variability (HRV) as an expression of the shift in the balance of the autonomic nervous system and the occurrence of postoperative inflammation and delirium. The main question it aims to answer is: Do patient with increased sympathetic nervous system activity develop postoperative delirium (POD) more often than patients with increased parasympathetic tone?
> 50 years of age
Scheduled for elective moderate to major risk traumatology or orthopedic surgery (excluding spine surgery) and anticipated duration of general anaesthesia ≥ 60 minutes.
Delirium before surgery.
Patients with emergency surgery
Contraindication to general anesthesia
ASA ≥ 4.
Patients \> 50 years undergoing surgery lasting at least 60 min
Other
Prospective
Not listed
Cognitive function at 90 days after surgery
Structured neurocognitive assessment using the test battery.
HRV and postoperative delirium
Comparison of heart rate variability before, during and after anaesthesia in patients with and without POCD.
neuro-degenerative/neuro-inflammation markers inflammatory
Correlation of the concentration of the biomarkers S-100B (µg/L), NSE (µg/L), NfL (pg/mL), CRP (mg/L) PCT (mg/L), IL-6 (pg/mL), TNF-alpha (ng/mL), in patients with and without POD/POCD
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