The purpose of this research study is to evaluate a new screening procedure for the early detection and monitoring of Age-related Macular Degeneration (AMD) in community settings and community hospital settings, to identify associated risk factors, and develop personalized monitoring strategies for at-risk individuals throughout the 5 years follow up period, which will allow us to establish prevalence, natural history of progression of early AMD in the community.
Adults aged 55 years or older
No severe systemic illnesses that prevent study participation
Willing and able to undergo protocol-required procedures for both eyes
Willing and able to provide written informed consent
Systemic disorders that preclude reliable clinical examination or multimodal imaging
Poor compliance or severe mental illness that hinders participation
Persons who are unable to give informed consent
This study will aim for 1500 participants aged ≥ 55 years from SingHealth Community Outreach Programme, other community-based screening initiatives and Outram Community Hospital (OCH).
Ecologic or community
Prospective
Not listed
To establish the natural history of AMD in Asian elderly and to identify clinical multimodal imaging, genetic, and metabolomic predictors of progression.
Progression is defined as the change from early signs of AMD to advanced AMD.
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Singapore National Eye Centre
Lead sponsor
Singapore Health Services
Collaborator
