Preoperative Deep Parasternal Intercostal Plane Block and Intraoperative Opioid Use in Cardiac Surgery

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorGaziantep City Hospital

About this trial

Median sternotomy is commonly used in cardiac surgery and is associated with significant intraoperative and postoperative pain, often requiring substantial opioid administration. High opioid use during cardiac surgery may contribute to adverse effects such as respiratory depression, delayed extubation, postoperative nausea and vomiting, and prolonged intensive care unit stay. Therefore, effective opioid-sparing strategies are an important component of modern perioperative care.

The deep parasternal intercostal plane (DPIP) block is a regional anesthesia technique that targets the anterior cutaneous branches of the intercostal nerves, which are responsible for transmitting pain from the sternum and adjacent tissues. When performed under ultrasound guidance, this block allows precise local anesthetic deposition while minimizing the risk of pleural or vascular injury.

The purpose of this randomized controlled study is to evaluate whether a preoperative ultrasound-guided DPIP block reduces intraoperative opioid consumption in adult patients undergoing elective cardiac surgery via median sternotomy. Patients will be randomly assigned to receive either a bilateral DPIP block in addition to standard general anesthesia or standard general anesthesia alone.

The primary outcome of the study is total intraoperative opioid consumption. Secondary outcomes include time to extubation, postoperative opioid consumption within the first 24 hours, postoperative pain scores, and the incidence of opioid-related adverse effects. The results of this study may help define the role of the DPIP block as part of a multimodal, opioid-sparing analgesic strategy in cardiac surgery.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

None

Disqualifiers

None

Trial design

Design model

Parallel

Treatments tested in this trial

  • Deep Parasternal Intercostal Plane Block

    Procedure/Surgery

    Bilateral ultrasound-guided deep parasternal intercostal plane block performed after induction of general anesthesia, with injection of local anesthetic into the fascial plane between the internal intercostal and transversus thoracis muscles for postoperative analgesia.

  • Standard Multimodal Analgesia

    Other intervention

    Standard postoperative multimodal analgesia administered according to institutional cardiac anesthesia protocols, without any regional anesthesia technique.

Treatment groups

80 Participants
are divided into 2 treatment groups
Group A: Deep Parasternal Intercostal Plane Block GroupExperimental treatment 1 intervention
Group B: Standard Analgesia (Control) GroupActive comparator 2 interventions

Trial outcomes

Primary outcomes

1

Total Intraoperative Opioid Consumption

Total amount of opioids administered intraoperatively, expressed as intravenous fentanyl equivalents (µg), adjusted for body weight (µg/kg), recorded from anesthesia records.

Time frame
From induction of general anesthesia until completion of surgery

Secondary outcomes

1

Intraoperative Hemodynamic Stability

Incidence of intraoperative hemodynamic instability, defined as the need for additional opioid administration or vasoactive support in response to surgical stimulation, recorded from anesthesia records.

Time frame
During surgery
2

Time to Extubation

Time elapsed between the end of surgery and successful tracheal extubation, recorded in minutes.

Time frame
From completion of surgery to successful tracheal extubation in the intensive care unit
3

Postoperative Opioid Consumption

Cumulative amount of opioids administered during the first 24 postoperative hours, expressed as intravenous morphine equivalents (mg), obtained from medical records.

Time frame
First 24 hours postoperatively
4

Time to First Rescue Analgesia

Time elapsed from arrival in the intensive care unit to the administration of the first rescue analgesic medication.

Time frame
Up to 24 hours postoperatively

Other outcomes

Sponsors and contacts

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