Probiotic-Based Versus Ethyl Lauroyl Arginate-Containing Mouthwashes on Streptococcus Mutans Counts, Dental Plaque Accumulation, and Salivary pH in a Group of Egyptian School Children

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age6-12
SponsorAl-Azhar University

About this trial

This study aims to compare the efficacy of probiotic-based mouthwashes versus ethyl lauroyl arginate-containing mouthwashes in reducing Streptococcus mutans count, dental plaque accumulation, and salivary pH among a group of Egyptian schoolchildren.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Healthy Egyptian schoolchildren aged 6-12 years.

Good general health.

Mild to moderate dental plaque accumulation.

Parental/caregiver willingness to provide consent

Disqualifiers

Antibiotic or antimicrobial use within the last month.

Allergies to the mouthwash components.

Systemic diseases affecting oral health.

Orthodontic appliances or extensive dental restorations.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Probiotic mouthwash

    Other intervention

    Patients will be receive probiotic mouthwash and instructed to rinse 5ml twice daily for 30 seconds for 28 days.

  • Ethyl lauroyl arginate mouthwash

    Other intervention

    Patients will be treated with ethyl lauroyl arginate mouthwash and instructed to rinse 5ml twice daily for 30 seconds for 28 days.

  • Professional prophylaxis (scaling + polishing)

    Other intervention

    Patients will receive professional prophylaxis (scaling + polishing) at baseline and will use only regular toothpaste twice daily, with no adjunctive mouthwashes over 28 days.

Treatment groups

66 Participants
are divided into 3 treatment groups
Group A: Group AExperimental treatment 1 intervention
Group B: Group BExperimental treatment 1 intervention
Group C: Group CActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

S. mutans count

S. mutans count will be measured at baseline (0 day) and post-intervention (28 days).

Time frame
28 days post-intervention

Secondary outcomes

1

Plaque index score

The plaque index score is classified as: * Score 0; No plaque * Score 1; Mild plaque accumulated along the gingival margin * Score 2; Moderate plaques accumulated along the gingival margin * Score 3; Heavy plaques accumulated along the gingival margin and adjacent tooth surface. Plaque index score will be measured at baseline (0 day) and post-intervention (28 days).

Time frame
28 days post-intervention
2

Salivary pH

Salivary pH measurements will be carried out by pH strips or pH meter.

Time frame
28 days post-intervention

Other outcomes

Sponsors and contacts

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