The aim of the work is to evaluate the impact of Probiotics supplementation on prevention of ventilator associated pneumonia in critically ill children admitted at Pediatric Intensive Care Unit at Tanta University Hospitals.
Critically ill children from 1 month to 18 years.
Both sexes.
Ventilated not due to chest infection.
Children recently received enteral vaccines.
Children receiving chronic immunosuppressive such as chemotherapy agents. and immunosuppressive medications, and high dose corticosteroids (more than 1 milligram per kilogram).
Children with contraindications of enteral feeding.
Children with gastrointestinal bleeding.
Parallel
Probiotics
DrugCritically ill ventilated children will receive standard management plus probiotics.
Standard management
Other interventionCritically ill ventilated children will receive standard management only.
Incidence of ventilator-associated pneumonia
Incidence of ventilator-associated pneumonia (VAP) diagnosed according to predefined CDC/NHSN pediatric criteria
Duration of mechanical ventilation
Duration of invasive mechanical ventilation will be measured in days from initiation of mechanical ventilation until successful extubation.
Pediatric intensive care unit length of stay
Pediatric intensive care unit (PICU) length of stay will be measured in days from PICU admission until PICU discharge.
Incidence of mortality
Incidence of mortality will be recorded.
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