Prognostic Power of the VEXUS Score in Septic Shock: Effectiveness in Mortality Prediction
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorAntalya Training and Research Hospital
About this trial
This study aims to evaluate the prognostic power of the VEXUS Score in predicting mortality among patients with septic shock in intensive care units.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age>18
Patients monitored for septic shock in intensive care unit
Signed informed consent
Disqualifiers
Age <18
Severe obesity precluding adequate ultrasonographic imaging.
Patients in whom venous structures cannot be clearly assessed via ultrasonography due to anatomical or technical reasons (e.g., adhesions following abdominal surgery).
Patients receiving dialysis due to chronic kidney disease or initiating dialysis for acute kidney failure.
Trial population
Adult patients admitted to the intensive care unit with a diagnosis of septic shock according to Sepsis-3 criteria. Patients will be enrolled consecutively from the intensive care unit of a tertiary care university hospital. Informed consent will be obtained from all patients or their legal representatives.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Serial VEXUS Ultrasound Evaluation
Diagnostic testUltrasound assessments will be performed by an experienced anesthesiologist at three time points (0-4 hours, 12-24 hours, and 72 hours)to determine the degree of venous congestion using the VEXUS Score. No treatment changes will be made based on the VEXUS findings. The scores will solely be used for prognostic correlation with mortality outcomes.
Treatment groups
100 Participants
are divided into 1 treatment groupGroup A: Septic shock cohort1 intervention
Trial outcomes
Primary outcomes
1
28-day intensive care unit mortality in relation to VEXUS score
Investigation of the relationship between VEXUS Score and 28-day mortality in patients diagnosed with septic shock in the intensive care unit.
Time frame
Up to 28 days following intensive care unit admission.Secondary outcomes
1
Need for mechanical ventilation in relation to VEXUS score
Evaluation of the association between initial VEXUS score and the requirement for mechanical ventilation in patients
Time frame
Within the first 72 hours of intensive care unit admission.2
Duration of mechanical ventilation in relation to VEXUS score.
Assessment of the correlation between VEXUS scores and the total duration of mechanical ventilation in intensive care unit patients with septic shock.
Time frame
From intensive care unit patients admission until extubation, up to 28 days.3
Length of intensive care unit stay in relation to VEXUS score
Investigation of the association between VEXUS score pregression and total length of intensive care unit stay in patients with septic shock.
Time frame
From intensive care unit admission until intensive care unit discharge, up to 28 days.4
Vasopressor dose and duration in relation to VEXUS score.
Assessment of the relationship between serial VEXUS scores and the cumulative dose and duration of vasopressor therapy during the first 72 hours in patients diagnosed with septic shock.
Time frame
First 72 hours after intensive care unit admissionSponsors and contacts
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Source ClinicalTrials.gov