Progression Patterns of Choroidal Venous Alterations
ConditionPachychoroid Disease
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age45+
SponsorSingapore National Eye Centre
About this trial
This study is about understanding how a condition called pachychoroid changes over time. Pachychoroid refers to an anatomic choroidal characteristic with abnormally thick choroid or abnormally dilated Haller's vessels. Pachychoroid can range from mild forms which does not cause any problems to more serious ones that might cause vision loss.This study will recruit participants with pachychoroid, to learn more about how this condition develops, how it affects people in the long run, and what factors might make it worse.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Adults aged 45 years or older.
Presence of pachyvessels on ultra-widefield (UWF) imaging in at least one quadrant.
Willing to undergo pupil dilation, and protocol-required procedures for both eyes
Willing to provide written informed consent
Disqualifiers
Presence of disorders of the ocular media which interfere with visual acuity and other ocular assessments during the study period
Eyes with other ocular pathology such as trauma, inflammation, previous intraocular surgery (except for cataract surgery)
Systemic diseases that might affect ocular blood flow such as uncontrolled hypertension, autoimmune disease, and haematological disorders
Pregnant or nursing women
Trial population
This study will aim to recruit 170 participants in Singapore National Eye Centre (SNEC) and 50 participants in National University Hospital, 30 participants from the University of Malaya
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
No trial groups listed
Trial outcomes
Primary outcomes
1
Progression of choroidal venous alterations
Proportion of eyes demonstrating progression of choroidal venous alterations, defined as either an increase in number of quadrants with pachyvessels or formation of new choroidal anastomoses.
Time frame
3 yearsSecondary outcomes
1
Incidence of progression of pachychoroid disease manifestation
New onset of Central Serous Chorioretinopathy (CSCR), focal Retinal Pigment Epithelium (RPE) changes, or other pachychorois related findings.
Time frame
3 years2
Risk factors associated with progression of choroidal venous alteration
Assessment of demographic, cilinical, and imaging parameters associated with progression.
Time frame
3 yearsSponsors and contacts
Click on the lead sponsor to view all of their trials.
Singapore National Eye Centre
Lead sponsor
National University Hospital, Singapore
Collaborator
University of Malaya
Collaborator
Hong Kong University
Collaborator
Source ClinicalTrials.gov