Protoacoustic Imaging For 3D Mapping
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversity of Oklahoma
About this trial
The purpose of this study is to test a new imaging technology called radioacoustic imaging (RAI) that may help doctors see where radiation is being delivered during proton therapy.
During proton therapy, the radiation treatment produces very small sound signals inside the body. This study will use special ultrasound sensors placed on the outside of the body to detect these signals. The information collected may allow researchers to create a picture showing where the radiation dose is being delivered in the body and how much radiation is reaching the treatment area.
The goal is to determine whether this technology can safely and accurately measure radiation during proton therapy without requiring any additional procedures or radiation exposure.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patients at least >18years old
Patients referred to OUHSC SCC for SOC PT
Patients receiving treatment for indications where RAI data collection is feasible (e.g., liver and prostate)
Willingness and ability to provide a documented informed consent
Disqualifiers
Patients with contraindications for ultrasound coupling (e.g., extensive open wounds or skin conditions at transducer placement sites).
Patients whose treatment plan or setup prevents the practical application of the RAI system without interfering with standard clinical care
Patients with implanted electronic devices (e.g., pacemakers) in the treatment region if there is any concern of device interference, even though the RAI system is passive.
Trial population
Recruitment will be for prostate and liver cancer patients only.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Radiacoustic Imaging w/Ultrasound.
DeviceA robotic arm will position the ultrasound matrix array on the lower abdomen.
Treatment groups
24 Participants
are divided into 1 treatment groupGroup A: Proton Therapy In Vivo1 intervention
Trial outcomes
Primary outcomes
1
Percentage of Liver Cancer Patients With Successful Respiratory Motion From Radiacoustic Imaging Tracking.
The dual-modality Radioacoustic Imaging integrated with Ultrasound (RAI/US) system in liver cancer patients is deployed to track respiratory motion, overlay real-time dose maps on ultrasound anatomy, and integrate adaptive feedback into the treatment workflow.
Time frame
1 yearSecondary outcomes
1
Percentage of Completed Workflow Treatment Plans Using Radiacoustic Imaging With Ultrasound In Prostate Cancer Patients.
Successfully develop a time-efficient RAI/US workflow for daily prostate cancer treatments, monitoring both intra- and inter-fractional motion, and applying geometric corrections to support adaptive planning.
Time frame
1 yearSponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov