Pyeloplasty in Pediatric Patients With Differential Renal Function Less Than 10%
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age1-18
SponsorTanta University
About this trial
This study aims to evaluate the postoperative outcomes of pyeloplasty in pediatric patients presenting with ureteropelvic junction obstruction and preoperative differential renal function less than 10%, focusing on:
* Improvement or stabilization of renal function after surgery. * Radiological improvement in hydronephrosis. * Clinical outcomes such as symptom relief and complication rates.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age from 1 month to 18 years.
Diagnosis of primary ureteropelvic junction obstruction.
Preoperative differential renal function <10% on MAG3 renogram.
A normal contralateral kidney.
Disqualifiers
Secondary Ureteropelvic Junction Obstruction (UPJO) (postoperative, traumatic, or secondary to other anomalies).
Solitary functioning kidney.
Associated vesicoureteral reflux or posterior urethral valves.
Severe comorbidities affecting renal function.
Trial population
This retrospective observational study will be conducted on 26 patients admitted at Urology Department, Tanta University Hospitals in the duration from June 2026 to June 2027.
Trial design
Design model
Other
Time perspective
Retrospective
Treatments tested in this trial
Pyeloplasty
Procedure/SurgeryPatients will undergo Anderson-Hynes dismembered pyeloplasty for primary ureteropelvic junction obstruction. The procedure was performed through an open, laparoscopic, or mini-incision approach according to the patient's age and the surgeon's clinical judgment. A ureteral stent was inserted when indicated.
Treatment groups
26 Participants
are divided into 1 treatment groupGroup A: Study group1 intervention
Trial outcomes
Primary outcomes
1
Change in Differential Renal Function After Pyeloplasty
Differential renal function of the affected kidney will be assessed using MAG-3 diuretic renography. Renal function will be classified as improved when differential renal function increases by at least 5 percentage points, stable when the change is less than 5 percentage points in either direction, and deteriorated when it decreases by at least 5 percentage points.
Time frame
6 months after pyeloplastySponsors and contacts
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Source ClinicalTrials.gov