Randomized active-sham controlled between-subject real-time fMRI neurofeedback trial aiming to modulate activity in the medial prefrontal cortex (mPFC) to improve subjective negative anticipation.
-Healthy subjects without any past or present psychiatric or neurological disorders
History of brain injury
Psychiatric or Neurological Disorder
Contraindications for MRI
Regular use of psychotropic substances (medication, drugs)
Parallel
real-time fMRI sham-controlled neurofeedback training procedure
Procedure/Surgeryreal-time fMRI neurofeedback training procedure running on the Turbo Brain voyager (TBV) 4.2 software (Brain Innovation, Maastricht, The Netherlands)
Neural activity of the medial prefrontal cortex (mPFC) based on blood oxygen level-dependent (BOLD) signal
Training-induced changes in mPFC activity will be assessed by analyzing BOLD-level activation of the mPFC
Training-related changes in anticipated anxiety
Participants will be required to rate the anticipated anxiety of future events using a Likert Scale ranging from 1 to 9 (1 = not at all anxious) and 9 = very anxious).
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