Reduction of Blood Recirculation in Veno-Venous ECMO
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorCharite University, Berlin, Germany
About this trial
Blood which recirculates through the circuit of a veno-venous Extracorporeal Membrane Oxygenation (V-V ECMO) does not contribute to the systemic oxygenation of a patient on V-V ECMO and is called the recirculation fraction (Rf). Theoretically, the optimization of ECMO blood flow is possible using Rf measurements.
A prospective, observational study will be performed measuring the Rf of total ECMO blood flow in patients with acute respiratory distress syndrome (ARDS) on V-V ECMO with an ultrasound dilution technique.
ECMO blood flow will be optimized by reducing ECMO blood flow in accordance with the measured Rf as long as systemic oxygenation is not compromised.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
None
Disqualifiers
None
Trial population
Inclusion Criteria: * patients aged 18 years or older * ARDS * veno-venous ECMO Exclusion Criteria: * age \< 18 years * hemodynamic instability during measurement of recirculation * pregnancy * inability to obtain patient's consent or consent of legal guardian
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
No trial groups listed
Trial outcomes
Primary outcomes
1
Successful ECMO blood flow reduction
Number of patients with a relevant recirculation fraction and successful ECMO blood flow reduction
Time frame
Once within the first week after initiation of ECMO therapySecondary outcomes
1
Recirculation fraction
Fraction of blood recirculating through the ECMO circuit
Time frame
Once within the first week after initiation of ECMO therapy2
Arterial blood oxygen content
Arterial blood oxygen content before vs. after reduction of ECMO blood flow
Time frame
Once within the first week after initiation of ECMO therapy3
Extracorporeal blood Flow
ECMO Blood Flow before vs. after reduction of ECMO blood flow
Time frame
Once within the first week after initiation of ECMO therapy4
Extracorporeal gas flow
ECMO Sweep Gas flow
Time frame
Once within the first week after initiation of ECMO therapySponsors and contacts
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Source ClinicalTrials.gov