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Regenerative Potentials of Mature Mandibular Molars With Symptomatic Irreversible Pulpitis Enhanced With Different Scaffolds

ConditionSymptomatic Irreversible Pulpitis (SIP)
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age15-40
SponsorCairo University

About this trial

The current study aims to assess the influence of different scaffolds on postoperative pain and success rate of pulpotomy in mandibular mature molars with symptomatic irreversible pulpitis

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

ASA I patients who are free from any physical or mental handicapping condition with no underlying systemic disease.

Age between 15-40 years.

Males & Females.

Patients' acceptance to participate in the trial.

Disqualifiers

Pregnant and lactating females.

Patients with physical or mental handicapping conditions.

Patients unwilling to participate in a 12-months follow up.

Immature roots.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Regenerative pulpotomy

    Procedure/Surgery

    Regenerative pulpotomy combines the use of hydraulic calcium silicate based cements; MTA, together with biodegradable scaffolds such as PRF.

Treatment groups

36 Participants
are divided into 3 treatment groups
Group A: Ascorbic acid augmented PRF scaffoldExperimental treatment 1 intervention
Group B: Tannic acid cross linked PRF scaffoldExperimental treatment 1 intervention
Group C: PRF scaffoldActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Intensity of postoperative pain

measured using numerical rating scale

Time frame
6, 12, 24, and 72 hours postoperatively

Secondary outcomes

1

Overall success rate

Based on clinical and radiographic signs and symptoms

Time frame
1, 3, 6, 9 and 12 months postoperatively.
2

IL-8 and TNF-α levels in pulpal blood

Time frame
Upon access cavity preparation

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Cairo University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: