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RePer-AGE: Reorganization of Visuo-cognitive Functions Based on Peripheral Vision With Aging

ConditionsAgingVisual PerceptionCognition
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-85
SponsorUniversity Hospital, Grenoble

About this trial

The RePer-AGE study investigates how central and peripheral vision contribute to visual recognition and how these mechanisms change with normal aging. The study is based on the hypothesis that peripheral vision provides rapid global information that supports visual recognition through predictive mechanisms. Healthy young adults (18-30 years) and older adults (60-85 years) will undergo visual psychophysical testing, ophthalmological examinations, and, for a subset of participants, functional magnetic resonance imaging (fMRI). The results are expected to improve our understanding of age-related changes in visuo-cognitive functions and provide reference data for future studies on age-related visual disorders.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Healthy young adults aged 18 to 30 years or healthy older adults aged 60 to 85 years.

Normal or corrected-to-normal visual acuity.

No ophthalmological disease affecting visual function.

For participants aged 60 years or older: Mini-Mental State Examination (MMSE) score ≥23.

Disqualifiers

None

Trial design

Design model

Parallel

Treatments tested in this trial

  • Psychophysical visual recognition tasks

    Behavioral

    Computerized visual recognition tasks assessing the respective contributions of central and peripheral vision to scene recognition and predictive visual processing.

  • Ophthalmological assessment

    Diagnostic test

    Ophthalmological examinations including retinal sensitivity (Humphrey automated perimetry) and low-luminance visual acuity.

  • Functional magnetic resonance imaging (fMRI)

    Diagnostic test

    Functional MRI performed during psychophysical visual recognition tasks to assess brain activity associated with visual recognition and predictive visual processing.

Treatment groups

160 Participants
are divided into 2 treatment groups
Group A: Psychophysics and OphthalmologyExperimental treatment 2 interventions
Group B: Psychophysics and Functional MRIExperimental treatment 2 interventions

Trial outcomes

Primary outcomes

1

Behavioral performance during scene categorization tasks

Behavioral performance will be assessed using accuracy and response time during computerized scene categorization tasks evaluating (1) central versus peripheral vision (EXC paradigm) and (2) semantic congruency between peripheral and central vision (VPC paradigm). Comparisons will be performed between young and older adults.

Time frame
Baseline (single experimental session)

Secondary outcomes

1

Retinal sensitivity

Retinal sensitivity measured by Humphrey 30-2 automated perimetry, including Mean Deviation (MD), Pattern Standard Deviation (PSD), and retinal sensitivity thresholds.

Time frame
Baseline
2

Brain activation during visual recognition

Blood oxygen level-dependent (BOLD) activity measured by functional magnetic resonance imaging during scene categorization tasks, including whole-brain analyses and regions of interest involved in visual recognition and predictive processing.

Time frame
Baseline

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University Hospital, Grenoble

Lead sponsor

Centre National de la Recherche Scientifique, France

Collaborator

University Grenoble Alps

Collaborator

National Research Agency, France

Collaborator

Source ClinicalTrials.gov

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