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Retinal and Choroidal Changes in Periodontal Disease

ConditionsPeriodontal DiseasesPeriodontal Diseases InflammationRetinal Thickening
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age20-54
SponsorZeliha Başak Çakır Erdil

About this trial

Advanced PeriodontitisIn this cross-sectional study, the relationship between periodontal disease severity and retinal and choroidal structural changes was evaluated using SD-OCT. Data from a total of 80 participants were examined. It was found that choroidal thickness increased and ganglion cell layer thickness decreased as periodontal disease severity increased, while no significant relationship was found in RNFL and IPL thicknesses. The findings support a possible association between periodontal disease and ocular structural changes.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

None

Disqualifiers

None

Trial population

The study population consisted of 80 systemically healthy, non-smoking adults who underwent comprehensive periodontal examination and spectral-domain optical coherence tomography (SD-OCT). Participants were classified into four groups according to their periodontal status (periodontally healthy, gingivitis, early periodontitis, and advanced periodontitis). All participants provided written informed consent before enrollment.

Trial design

Design model

Other

Time perspective

Cross-sectional

Treatments tested in this trial

Not listed

Trial groups

80 Participants
are grouped into 4 trial groups
Group A: Periodontal Healthy
Group B: Gingivitis
Group C: Early Periodontitis
Group D: Advanced Periodontitis

Trial outcomes

Primary outcomes

1

Correlation Between Periodontal Disease Severity and Choroidal Thickness

The correlation between periodontal disease severity and choroidal thickness will be assessed using Spearman's correlation coefficient (rₛ). Periodontal disease severity will be assessed using probing pocket depth (PPD) and clinical attachment level (CAL), measured in millimeters (mm) using a periodontal probe. Choroidal thickness will be measured in micrometers (µm) using spectral-domain optical coherence tomography (SD-OCT).

Time frame
Baseline

Secondary outcomes

1

Correlation Between Periodontal Disease Severity and Retinal Nerve Fiber Layer (RNFL) Thickness

The correlation between periodontal disease severity and retinal nerve fiber layer (RNFL) thickness will be evaluated. Periodontal disease severity will be assessed using clinical periodontal parameters, including probing pocket depth (PPD) and clinical attachment level (CAL), measured in millimeters (mm). RNFL thickness will be measured in micrometers (µm) using spectral-domain optical coherence tomography (SD-OCT). The correlation will be quantified using Spearman's correlation coefficient (rₛ).

Time frame
Baseline
2

Correlation Between Periodontal Disease Severity and Ganglion Cell Layer (GCL) Thickness

The correlation between periodontal disease severity and ganglion cell layer (GCL) thickness will be evaluated. Periodontal disease severity will be assessed using clinical periodontal parameters, including probing pocket depth (PPD) and clinical attachment level (CAL), measured in millimeters (mm). GCL thickness will be measured in micrometers (µm) using spectral-domain optical coherence tomography (SD-OCT). The correlation will be quantified using Spearman's correlation coefficient (rₛ).

Time frame
Baseline
3

Correlation Between Periodontal Disease Severity and Inner Plexiform Layer (IPL) Thickness

The correlation between periodontal disease severity and inner plexiform layer (IPL) thickness will be evaluated. Periodontal disease severity will be assessed using clinical periodontal parameters, including probing pocket depth (PPD) and clinical attachment level (CAL), measured in millimeters (mm). IPL thickness will be measured in micrometers (µm) using spectral-domain optical coherence tomography (SD-OCT). The correlation will be quantified using Spearman's correlation coefficient (rₛ).

Time frame
Baseline

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Zeliha Başak Çakır Erdil

Lead sponsor

Adiyaman University

Sponsor institution

Source ClinicalTrials.gov

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