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Revascularization of Young Immature Permenant Teeth Using Different Types of Intra Canal Medication

ConditionsTraumatic TeethNecrotic Teeth
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age7-13
SponsorAl-Azhar University

About this trial

Evaluation of the Effect of Grape Seed Extract, Glycyrrhizin Compared to Triple Antibiotic Paste as Intra Canal Medication in Revascularization of Necrotic Permanent Immature Teeth in Children: A Randomized Clinical Trial

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Healthy children aged from 7-13 years old.

Patient with necrotic pulp.

Open apex.

Disqualifiers

Teeth with root fractures.

Presence of root resorptions.

Presence of periodontal pockets.

Developmental anomalies.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Grape Seed Extract

    Drug

    Grape seed extract in form of hydrogel with concentration 6.5 % left in canal for one week

  • Glycyrrhizin

    Drug

    Glycyrrhizin hydrogel 50 micrograms in 1 milligram left in canal for one week

  • Triple Antibiotic Paste

    Drug

    Trple antibiotic paste Left for one week

Treatment groups

45 Participants
are divided into 3 treatment groups
Group A: Group aActive comparator 1 intervention
Group B: Group bExperimental treatment 1 intervention
Group C: Group cExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Digital count of e.faecalis

Microbiological evaluation The number of E. faecalis will be digitally counted.

Time frame
After One week of mediation application
2

Clinical evaluation success will be assessed using following criteria of success according to scoring system Absence of : - Pain, - Soft tissue swelling - soft tissue inflammation - Sinus tract - tenderness to percussion - tooth mobility

Clincal success will be assessed using following criteria of success according to clinical scoring system Absence of : * Pain, * Soft tissue swelling * soft tissue inflammation * Sinus tract * tenderness to percussion * tooth mobility. Clinical score Clinical symptom Definition 1. asymptomatic Pathology: absent Normal functioning Mobility (physiological) ≤1mm 2. Slight discomfort, short-lived Pathology: questionable Percussion sensitivity Gingival inflammation (due to poor oral hygiene) Mobility (physiological) \> 1mm, but \<2mm 3. Minor discomfort, short-lived Pathology: initial changes present Gingival swelling (not due to poor oral hygiene) Mobility \> 2mm, but \< 3 mm 4. Major discomfort, long-lived extract immediately Pathology: late changes present Spontaneous pain Gingival swelling (not due to poor oral hygiene) Periodontal pocket formation(exudate) Sinus tract present Mobility ≥ 3mm Premature tooth loss, due to pathology

Time frame
After one week of mediation application

Secondary outcomes

1

Radiographic evaluation

After tweleve months take periapical radiograph to detection normal lamina dura and increase in root thikness and length. Criteria for success according to radiographic scoring system

Time frame
After tweleve month

Other outcomes

Sponsors and contacts

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Al-Azhar University

Lead sponsor

Source ClinicalTrials.gov

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