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Risk Factors of Extubation Failure in PICU Patients

ConditionExtubation Failure
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age30-18
SponsorSohag University

About this trial

Up to 20% of MV patients experience EF \[10\]. EF is defined as the need to reinsert the endotracheal tube to resume MV in patients extubated for less than 48 hours. It has high rates of morbidity and mortality, prolongs the duration of MV and thus causes a longer stay in the PICU and risk of complications such as the need for tracheostomy, the incidence of pneumonia and pulmonary damage, and finally, costs increase as well and death \[10, 11\] .

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

All patient at PICU < 18 years subjected to MV through an endotracheal tube at least >12 hours.

Patients eligible for weaning from MV according to the weaning criteria (Evidence for some reversal of the underlying cause following for respiratory failure, Adequate oxygenation" PaO2/FIO2 ratio ≥ 200, FIO2 ≤ 0.40, PaO2 ≥ 60, PaCO2 ≤ 60 and PEEP ≤ 5 cmH2O.", PH ≥ 7.25, Respiratory rate (RR) ≤ 45 bpm, Heart rate (HR) ≤ 140 bpm,(rapid shallow breathing index = tidal volume / RR) RSBI ≤ 8 breaths/min/ml/kg body weight, Hemodynamic stable, no or minimal vasopressor or inotropes"[1,12],.

Appropriate level of consciousness, No continuous sedation infusion nor neuromuscular blocking agents, afebrile, adequate hemoglobin ≥ 7.5 g/dl and/or no evidence of hemorrhage.

Disqualifiers

Patients less than 30 days.

Tracheostomized patients.

Death on mv ≤ 12 hours.

Unplanned extubation.

Trial population

Patients in PICUS in Sohag University Hospitals.

Trial design

Design model

Case-control

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

100 Participants
are grouped into 2 trial groups
Group A: A:successful extubation
Group B: B: failed extubation

Trial outcomes

Primary outcomes

1

successful extubation and weaning from mechanical ventilation

passing spontaneous trial and air leak test and not requiring to be re-intubated within 2 days

Time frame
48 hours
2

failed extubation , failed weaning from mechanical ventilation

not passing spontaneous trial and air leak test and not requiring to be re-intubated within 2 days

Time frame
48 hours

Secondary outcomes

1

survival or death

weaning from mechanical ventilation and improvement of the cause of intubation

Time frame
30 days

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Sohag University

Lead sponsor

Source ClinicalTrials.gov
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