This randomized controlled trial will compare oral furosemide with placebo for improving blood pressure control in women with severe preeclampsia after delivery. Participants will receive either 20 mg of furosemide or a placebo tablet once daily for 5 days, in addition to standard postpartum treatment for high blood pressure. Blood pressure, symptoms, adverse events, and the need for additional antihypertensive medication will be monitored for 7 days after delivery. The study will assess whether adding furosemide helps achieve better postpartum blood pressure control compared with placebo.
Women aged 18 to 45 years
Any parity
Gestational age >28 weeks based on LMP
Severe preeclampsia as per the study operational definition
Pre-existing renal dysfunction or serum creatinine >1.2 mg/dL on medical record
Significant hypokalemia (K <3 mEq/L) before enrollment
Known rheumatologic disease or advanced diabetes
History of allergy to furosemide or prior use of diuretics before randomization
Parallel
Furosemide and Potassium
DrugFurosemide 20 mg tablet administered orally once daily for 5 days after delivery as an add-on to standard postpartum antihypertensive treatment.
Placebo
DrugPlacebo tablet administered orally once daily for 5 days after delivery, in addition to standard postpartum antihypertensive treatment, including blood pressure monitoring and labetalol when required.
Blood pressure
Proportion of participants achieving blood pressure below 140/90 mmHg on two readings taken 48 hours apart, with no systolic blood pressure ≥160 mmHg or diastolic blood pressure ≥110 mmHg, and no need for an increase in antihypertensive medication from delivery through 7 days postpartum.
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