Scoliosis and Functional Outcomes in Children With Juvenile Idiopathic Arthritis
ConditionScoliosis
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age8-18
SponsorIstanbul University
About this trial
Juvenile idiopathic arthritis (JIA) is a chronic inflammatory disease that may affect musculoskeletal development and posture in children. Spinal involvement, including scoliosis, is not routinely evaluated in clinical practice despite its potential impact on functional status and quality of life.
This cross-sectional study aims to assess the presence of scoliosis in children with JIA and to investigate its association with functional status, postural alignment, and disease activity. Clinical and functional parameters will be analyzed to better understand the impact of spinal deformities in this population.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Age between 8 and 18 years at the time of enrollment
Diagnosis of juvenile idiopathic arthritis (JIA) according to ILAR criteria
Written informed consent obtained from parent/legal guardian and assent from the child/adolescent, when appropriate
Disqualifiers
Known scoliosis due to non-JIA causes (e.g., congenital vertebral anomalies, neuromuscular disorders, or syndromic scoliosis)
History of prior spinal surgery or current brace treatment for scoliosis
History of significant spinal trauma or spinal infection/tumor affecting spinal alignment
Presence of coexisting chronic conditions that significantly affect posture, gait, or functional testing (e.g., severe neurologic impairment) and may confound assessments
Trial population
The study population consists of children and adolescents aged 8-18 years diagnosed with juvenile idiopathic arthritis (JIA) according to ILAR criteria and followed up at a tertiary pediatric rheumatology center. Participants will be recruited consecutively during routine outpatient visits. The aim of the study is to evaluate the prevalence and severity of scoliosis, as defined by Cobb angle measurements on physical examination and, if necessary, standing spinal radiographs, and to examine its relationship with clinical and functional parameters. Both patients with and without scoliosis will be included in the study.
Trial design
Design model
Cohort
Time perspective
Cross-sectional
Treatments tested in this trial
Not listed
Trial groups
200 Participants
are grouped into 2 trial groupsGroup A: JIA Patients With Scoliosis
Group B: JIA Patients Without Scoliosis
Trial outcomes
Primary outcomes
1
Prevalence of Scoliosis in Children With Juvenile Idiopathic Arthritis
Proportion of participants with scoliosis, defined as a Cobb angle ≥10° measured on standing spinal radiographs.
Time frame
At baseline (single study visit)Secondary outcomes
1
Scoliosis Severity (Cobb Angle)
Cobb angle (degrees) measured on standing spinal radiographs. Scoliosis defined as Cobb angle ≥10°.
Time frame
At baseline (single study visit)2
Health-Related Quality of Life (PedsQL)
Health-related quality of life assessed using the Pediatric Quality of Life Inventory (PedsQL) total score (and physical and psychosocial subscale scores, if available). Scores are transformed to a 0-100 scale (range: 0-100), with higher scores indicating better health-related quality of life.
Time frame
At baseline (single study visit)Locations
Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: