"Screening for Change: Early Risk Detection and Integrated Prevention for Diabetes and Cardiovascular Diseases in the Marche Region"

To assess the screening adherence through coverage

This outcome will be assessed computing the percentage (%) of screening participants against invited

To evaluate the 10-years risk of developing Type 2 Diabetes event for each person

This outcome will be assessed evaluating the scores derived from FINDRISC tool, along with Glycated Hemoglobin (HbA1c), to determine risk of developing diabetes. FINDRISC uses: * age (score=2 for people aged 50 years) * vegetable \& fruit intake (every day=0; otherwise= 1) * history of hyperglycemia (no=0; yes=5; ) * Body Mass Index (BMI) (kg/m\^2) (from 0 to 3, as increases) * physical activity (yes=0; no=2) * medical treatment of hypertension (yes=2; no=1) * family history of diabetes (no=0; otherwise, up to 5) * waist circumference (cm) (from 0 to 4, as increases) The detection of the HbA1c will be conducted for the moderate, high and very high-risk levels, to accurately complete the risk assessment for results \>9, a cut-off level suggestive of further investigation, as per literature. Based on the final score, ranging from 0 to 26, four risk levels are defined: I- Low risk (≤9); II- Moderate risk (\>9≤15 score); III: High risk (\>15 ≤20 score); IV- Very high risk (\> 20 score).

To evaluate the 10-years risk of developing a major Cardiovascular risk event for each person

This outcome will be assessed evaluating the scores derived from CUORE tool, representing the probability of experiencing a first major cardiovascular event (myocardial infarction or stroke) in the next 10 years, based on 8 risk factors: gender, age, diabetes, smoking habit, systolic blood pressure (mmHg), total cholesterolaemia (mg/dl), High-Density Lipoprotein-cholesterolaemia (mg/dl) and anti-hypertensive treatment. The individual score is computed by the formula: 1 - \[S(t)\] \^ {EXP \[β1 × age + β2 × PAS + β3 × COL + β4 × HDL + β5 (if SMOKER) + β6 (if DIABETIC) + β7 (if TREATED with antihypertensives) - G(µ)\]}; S(t)=10-year survival evaluated at the mean value of the factors; βi= the coefficients of the risk factors; G(µ)= linear combination of the factor averages or prevalence in each cathegory by the respective coefficients βi. Based on the final score (from 0% to 100%), 3 risk levels are identified: I- Low risk: \<3%; II- Moderate risk: ≥3-\<20%; III: High risk: ≥20%.

To determine the Diabetes Mellitus Type 2 risk detection rate

This outcome will be assessed evaluating the proportion of persons with unrecognized risk of developing Diabetes Mellitus Type 2, by using the final scores from the FINDRISC tool, along with Glycated Hemoglobin, when foreseen. This detection rate is calculated as the proportion of individuals identified as having moderate, high, or very high risk of developing diabetes over the next decade, based on the FINDRISC scores.

To determine the Cardiovascular Diseases' risk detection rate

This outcome will be assessed evaluating the proportion of persons with unrecognized risk of developing a major Cardiovascula Diseases, by using the final scores from the CUORE tool, which predicts the probability of experiencing a first major cardiovascular event (such as myocardial infarction or stroke) within the next 10 years This detection rate is calculated as the proportion of individuals identified as having moderate, high, or very high risk of developing cardiovascular disease over the next decade, based on the CUORE score.