Short-Term Tocolysis in Preterm Labor

ConditionPreterm Labor

Trial statusNot yet recruiting

Trial phaseNot listed

Trial typeObservational

Biological sexFemale

Age18-45

SponsorSohag University

About this trial

The aim of this study is to identify independent prognostic factors associated with the success of short-term tocolysis, defined as delivery delayed by at least 48 hours, in women with singleton preterm labor

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age from 18 to 45 years old.

Singleton Pregnancy

Gestational age between 24 and 34 weeks, confirmed by last menstrual period and/or first-trimester ultrasound.

Diagnosis of preterm labor, defined as Regular uterine contractions (≥4 in 20 minutes recorded in CTG) with a documented change in cervical dilation (e.g., from<1 cm to ≥2 cm) or, in nulliparous women, a dilation of ≥2 cm

Disqualifiers

Evidence of chorioamnionitis or intrauterine infection.

Preterm premature rupture of membranes (PPROM).

Maternal medical disorders contraindicating tocolysis, such as severe preeclampsia, significant cardiac disease, or uncontrolled diabetes mellitus.

Contraindications to continuation of pregnancy, including placental abruption or placenta previa with bleeding.

Trial population

All participants will receive short-term tocolytic therapy according to the unit protocol. * The choice of tocolytic agent (., Magnesium sulphate ) will be determined by the treating physician. * Tocolysis will be administered for a maximum duration of 48-72 hours. * Antenatal corticosteroids (Betamethasone amp 12mg once daily for 2days) will be administered to eligible participants to enhance fetal lung maturity. * Failure documented when there is efficient uterine contractions more 4/10mins each one lasts more than 40 seconds, and there was progressive cervical dilatation more 3cm

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

No trial groups listed

Trial outcomes

Primary outcomes

Successful short-term tocolysis, defined as postponement of delivery for at least 48 hours after initiation of tocolytic therapy

Time frame

48 hours

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Sohag University

Lead sponsor

Source ClinicalTrials.gov

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