This retrospective single-center observational study will evaluate the impact of age on the diagnostic performance of the sural-to-radial sensory nerve amplitude ratio (SRAR) in patients with length-dependent and non-length-dependent peripheral sensory polyneuropathies. Clinical and electrophysiological data collected during routine care between January 2013 and July 2026 will be analyzed. Diagnostic performance will be assessed using receiver operating characteristic (ROC) curve analysis across predefined age groups to determine whether age-adjusted SRAR thresholds improve the differentiation between the two polyneuropathy phenotypes.
Adults aged 18 years or older.
Diagnosis of peripheral sensory polyneuropathy.
Classification as length-dependent (LDN) or non-length-dependent (NLDN) based on clinical and electrophysiological findings.
Available nerve conduction study including sural and radial sensory nerve amplitudes allowing calculation of the SRAR.
Missing or incomplete clinical or electrophysiological data preventing SRAR calculation.
Unclassifiable neuropathy phenotype.
Technical factors affecting the reliability of nerve conduction studies.
Adult patients with peripheral sensory polyneuropathies evaluated at the Peripheral Neuromuscular Rare Disease Reference Center of Nice University Hospital between January 2013 and July 2026. Patients will be classified into length-dependent or non-length-dependent phenotypes and stratified into predefined age groups for analysis.
Other
Retrospective
Retrospective Medical Record Review
Other interventionThis observational study involves retrospective collection and analysis of routinely acquired clinical and electrophysiological data from approximately 180 patients with sensory polyneuropathy. Data extracted from medical records include demographic characteristics, clinical diagnosis, and nerve conduction study parameters, including sural and radial sensory nerve action potential amplitudes used to calculate the sural/radial amplitude ratio (SRAR). No additional diagnostic procedures, treatments, or study-specific assessments are performed. All data are obtained from standard clinical care.
Diagnostic performance of the sural-to-radial sensory nerve amplitude ratio (SRAR)
To evaluate the diagnostic performance of the SRAR for differentiating length-dependent (LDN) from non-length-dependent (NLDN) peripheral sensory polyneuropathies according to age group, using receiver operating characteristic (ROC) curve analysis.
Age-specific optimal SRAR diagnostic thresholds
To determine the optimal SRAR cutoff values for each predefined age group using the Youden index derived from ROC curve analysis.
Comparison of SRAR values between LDN and NLDN
To compare SRAR values between patients with length-dependent and non-length-dependent peripheral sensory polyneuropathies and to assess the influence of age on these values.
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