The aim of the research study is to look at a new type of MRI scanning that can measure the amount of sodium in different parts of the body. Sodium (or 'salt') levels are very important in maintaining health, and high levels lead to high blood pressure. This is very important to patients with kidney disease, as the kidney is the main organ that regulates the amount of sodium in the body. It is possible to measure blood sodium levels, but this does not tell us how much sodium is present in other areas of the body. Previously, it has not been possible measure this. Sodium MRI (Na-MRI) is a new type of MRI scanning that can directly measure sodium in other parts of body such as skin, muscles, kidneys, and brain. The investigators believe that this will help to guide treatment in patients with kidney disease who are on haemodialysis, research studies are needed to prove the benefits.
Age 50-75 years inclusive
Male and female patients with CKD stage 5 receiving chronic haemodialysis
Patient has been dialysis dependent for at least 3 months
Must be able to follow simple instruction in English (on safety ground for MRI scans) and be able to understand the nature and requirements of the study
Active infection or malignancy
Amputee
Pregnancy
Contraindication to MRI scanning including claustrophobia, pacemaker, metallic implants etc
10 participants (5 male and 5 female) who are over 50 and under 75 years old who have been on haemodialysis for more than 3 months
Cohort
Prospective
Not listed
Proportion of brain images that can be analysed for sodium levels
success criterion \> 85%
Change in grey and white matter sodium levels
comparing before and after dialysis
Association between change in brain sodium levels to proton MRI measures
grey/white matter volume, T1
Click on the lead sponsor to view all of their trials.
University Hospitals of Derby and Burton NHS Foundation Trust
Lead sponsor
University of Nottingham
Collaborator
