Specific Methylation Profiles in HNSCC
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorAalborg University Hospital
About this trial
In the study, N-20190047, the investigators aim to define specific methylation patterns in a group of patients with head and neck squamous cell carcinomas.
With this study the investigators aim to validate these findings in a larger cohort.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Written informed consent
Verified head and neck squamous cell carcinoma
Disqualifiers
Other active cancer
Uncontrolled comorbidity
Unable to give informed consent
Written informed consent
Trial population
Cancer group: Patients referred from the region of Northern Denmark to the Department of Otorhinolaryngology - Head and Neck Surgery with suspicion of, or with already verified Head and neck squamous cell carcinoma. Only patients with verified squamous cell carcinoma after diagnostic work-up will be eligible. Control group: Patients referred from the region of Northern Denmark to the Department of Otorhinolaryngology - Head and Neck Surgery for evaluation or treatment, but without suspected or verified malignancy of the head and neck.
Trial design
Design model
Case-control
Time perspective
Prospective
Treatments tested in this trial
Blood sample
Diagnostic testA separate blood sample will be taken for methylation-analyses
Treatment groups
300 Participants
are divided into 2 treatment groupsGroup A: Cancer group1 intervention
Group B: Control group1 intervention
Trial outcomes
Primary outcomes
1
Diagnostic accuracy
How accurate can the methylation profiles diagnose the head and neck squamous cell carcinoma
Time frame
At diagnosisSponsors and contacts
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Source ClinicalTrials.gov