Health TrialsbyHealthPanel

Targeted Assessment of Cognition and Tactical-performance With Ingested Ketones

ConditionCognition
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorFlorida State University

About this trial

The goal of this study is to determine whether consuming a commercially available exogenous ketone supplement (KetoneIQ®) affects cognition, specifically marksmanship, under physical stress (i.e., exhaustive exercise).

The main questions we seek to answer are:

* Does the supplement save cognitive performance under stress compared to a placebo? * Does the supplement improve marksmanship under stress compared to a placebo?

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Active Member of an accredited Law Enforcement Special Weapons and Tactics Team (SWAT)

Health and capable of meeting testing requirements

Disqualifiers

Following a low-carbohydrate ketogenic diet

Self-reported Pregnancy

Allergy to testing materials

Currently using exogenous ketone supplements within one week of testing

Trial design

Design model

Crossover

Treatments tested in this trial

  • KetoneIQ®

    Dietary supplement

    Acute dosage at 0.6g/kg of bodyweight, split into 2 boluses of 0.4 and 0.2g/kg seperated by 45 mins

  • Placebo

    Dietary supplement

    Taste, texture, and color matched very low calorie placebo

Treatment groups

20 Participants
are divided into 2 treatment groups
Group A: KetoneIQ®Experimental treatment 1 intervention
Group B: PlaceboPlacebo comparator 1 intervention

Trial outcomes

Primary outcomes

1

Cognitive Performance

Changes in Score for the Trail Making Test, Psychomotor Vigilance Test, and Flanker Test.

Time frame
Baseline (minute 0) to Post Suppelementation (minute 45) to Post Exercise (minute 60)

Secondary outcomes

1

Changes in Circulating Concentration of Brain Derieved Neurotrophic Factor

To assess changes in BDNF from baseline to post supplementation to post exercise

Time frame
Baseline (minute 0) to post supplementation (minute 45) to post exercise (minute 60)
2

Changes in Circulating Catecholamines Concetrations

To assess changes in the circulating concentration of epinephrine, norepinephrine, and dopamine

Time frame
From baseline (minute 0) to post supplemenation (minute 45) to post exercise (minute 60)
3

Changes in Circulating Cortisol Concentration

To assess changes in circulating cortisol between groups

Time frame
From baseline (minute 0) to post supplemetation (minute 45) to post exercise (minute 60)
4

Weapons Familarization Score

To assess whether potentially improved cognitive performance translates to tactical-specific tasks. Rifle disassembly, reassembly, and functions check. This will be quantified by number of errors and time to completion

Time frame
Post Exercise (minute 60)

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Florida State University

Lead sponsor

Source ClinicalTrials.gov
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