The Correlation of Lewis Antigens With VTE
ConditionThromboembolic Disease
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-78
SponsorLarissa University Hospital
About this trial
The goal of this observational study is to learn if certain factors in a person's blood are linked to a history of venous thromboembolic disease (VTED), which includes conditions like deep vein thrombosis.
Lewis system antigens are natural markers found on red blood cells. Past research suggests that people without these specific markers might have a higher chance of developing heart disease, but the link to blood clots in veins is not well understood.
This study aims to answer:
* Are certain Lewis antigen types more common in people with a history of VTE? * Do the Lewis antigen results relate to other known blood clot risk factors? Researchers will identify Lewis a and b antigens in 100 participants who attend the Haemostasis Disorders Clinic at the University Hospital of Larissa. All participants are people with a personal history of deep vein thrombosis, with or without an inherited or acquired tendency for blood clots.
Researchers will also record other known risk factors for VTED for each participant. This study is self-funded.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Adult patients aged 18-78 years with a personal history of deep venous thrombosis and/or Pulmonary Embolism.
Disqualifiers
Current pregnancy or postpartum period 2. Hepatic insufficiency 3. Alcoholic cirrhosis
Trial population
Pateints with personal history of VTE
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
200 Participants
are grouped into 2 trial groupsGroup A: Patients with personal history of VTE
Group B: CONTROL GROUP- VOLUNTEERS BLOOD DONORS
Trial outcomes
Primary outcomes
1
The aim of this study is to investigate the relationship between Lewis system antigens and venous thromboembolic disease (VTED).
Lewis a and b antigens will be identified in patients with a personal history of deep vein thrombosis, with or without hereditary or acquired thrombophilia, who are being monitored at the Haemostasis Disorders Clinic of the Blood Transfusion Service of the University Hospital of Larissa. All patients, after being informed, will submit written consent for their participation in the study. Lewis antigens will be identified serologically using reagents and gel cards from Grifols. The results of the thrombophilia test and other known risk factors for VTE will be recorded. Statistical analysis will be performed using the SPSS package.
Time frame
From enrollment to the day of blood phenotyping- approximately 48 hours2
PRESENCE OF LEWIS A AND B ANTIGEN ON ERYTHROCYTE
NEGATIVE OR POSITIVE FOR LEWIS ANTIGENS
Time frame
From enrollment to the day of blood antigen phenotyping- approximately 48 hoursLocations
Sponsors and contacts
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Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: