Breast cancer is frequently accompanied by chronic inflammation, malnutrition, and reduced quality of life, all of which may compromise treatment response and clinical outcomes. Nutritional interventions with immunomodulatory and anti-inflammatory properties have the potential to improve these conditions. Channa striata is rich in high-quality protein, albumin, and essential amino acids that support nutritional recovery and tissue repair, while Curcuma contains curcumin, a bioactive compound with well-established anti-inflammatory and antioxidant effects. This study aims to evaluate the effect of combined Channa striata and Curcuma supplementation on nutritional status, serum interleukin-6 (IL-6) levels, and quality of life in patients with breast cancer undergoing treatment. The findings are expected to provide evidence for the use of this nutritional supplementation as a complementary strategy to improve clinical outcomes, reduce systemic inflammation, and enhance the overall well-being of breast cancer patients.
Female patients with breast cancer aged ≥18 years who were undergoing chemotherapy.
Patients with a body mass index (BMI) of 18-29 kg/m².
Patients currently receiving chemotherapy for breast cancer.
Patients with serum albumin levels of 2.0-3.5 g/dL.
Patients with chronic kidney disease, renal failure, or kidney infection.
Patients with a known allergy to fish or Channa striata (snakehead fish) albumin-derived products.
Patients receiving other protein or amino acid supplements during the study period.
Patients who were non-compliant or discontinued the intervention before completion of the study.
DINA KEUMALA SARI
Lead sponsor
Universitas Sumatera Utara
Sponsor institution