About this trial
Breast cancer is frequently accompanied by chronic inflammation, malnutrition, and reduced quality of life, all of which may compromise treatment response and clinical outcomes. Nutritional interventions with immunomodulatory and anti-inflammatory properties have the potential to improve these conditions. Channa striata is rich in high-quality protein, albumin, and essential amino acids that support nutritional recovery and tissue repair, while Curcuma contains curcumin, a bioactive compound with well-established anti-inflammatory and antioxidant effects. This study aims to evaluate the effect of combined Channa striata and Curcuma supplementation on nutritional status, serum interleukin-6 (IL-6) levels, and quality of life in patients with breast cancer undergoing treatment. The findings are expected to provide evidence for the use of this nutritional supplementation as a complementary strategy to improve clinical outcomes, reduce systemic inflammation, and enhance the overall well-being of breast cancer patients.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Female patients with breast cancer aged ≥18 years who were undergoing chemotherapy.
Patients with a body mass index (BMI) of 18-29 kg/m².
Patients currently receiving chemotherapy for breast cancer.
Patients with serum albumin levels of 2.0-3.5 g/dL.
Disqualifiers
Patients with chronic kidney disease, renal failure, or kidney infection.
Patients with a known allergy to fish or Channa striata (snakehead fish) albumin-derived products.
Patients receiving other protein or amino acid supplements during the study period.
Patients who were non-compliant or discontinued the intervention before completion of the study.
Trial design
Parallel
Treatments tested in this trial
channa striata and curcuma
Dietary supplementParticipants in the intervention group received oral supplementation consisting of 5 g of Channa striata and 250 mg of Curcuma daily for one month, while participants in the control group received a maltodextrin placebo daily for the same duration.
Maltodextrin (Placebo)
Dietary supplementParticipants in the control group received a placebo consisting of maltodextrin daily for one month.
Treatment groups
Trial outcomes
Primary outcomes
Nutritional status
This study evaluated changes in BMI, following one month of Channa striata and Curcuma supplementation.
Secondary outcomes
interleukin - 6
Change in serum interleukin-6 (IL-6) concentration from baseline to 1 month after daily supplementation with Channa striata and Curcuma in patients with breast cancer undergoing chemotherapy
Sponsors and contacts
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DINA KEUMALA SARI
Lead sponsor
Universitas Sumatera Utara
Sponsor institution
This trial is not recruiting at the moment. You can still explore other options: