Obesity is a risk factor for chronic diseases, and improving energy expenditure is a way to prevent and treat obesity. The purpose of this project is to explore the relationship between the effect of coffee on energy expenditure and caffeine metabolism, which has important significance in the rational application of caffeine.
Healthy adults.
Must be able to drink coffee.
Diabetes.
Hypoglycemia.
Gout.
Osteoporosis.
Parallel
Caffeine content
Other interventionParticipants will drink the same volume of water or coffee, caffeine content is 2mg/kg by body weight.
Total energy expenditure
Total energy expenditure will be measured by Chamber (OMNICAL).
The concentration of caffeine and its metabolites in urine
The contents of caffeine and it's metabolites will be measured by gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS ).
The concentration of caffeine and its metabolites in serum
The concentration of caffeine and its metabolites in serum will be measured by gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS ).
Body temperature
Body temperature of participants will be measured by body temperature patch (RIT-P02-MED).
Electrocardiogram (ECG)
ECG of participants will be measured by Amu ECG belt, the changes in P wave, PR interval, PR segment, QRS wave group, J point, ST segment, T wave, QT interval, and U wave will be observe.
Blood pressure
Systolic and diastolic blood pressure of participants will be measured by Omron digital sphygmomanometer.
Height
Height will be measured by seca 217 stable stadiometer. Subjects wearing no shoes.
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