Health TrialsbyHealthPanel

The Effect of Nonverbal Vocalisations on Pain Tolerance

ConditionHealthy
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-60
SponsorCentre Hospitalier Universitaire de Saint Etienne

About this trial

Humans produce non-verbal vocalizations (shouting, growling, screaming), laughter, ...) in various contexts that are likely to perform biological functions.

and important social issues. Yet despite their importance in the human vocal repertoire, the mechanisms and functions of non-verbal vocalizations remain little studied and poorly understood including in humans. In this context, the investigators wish to examine how the production of vocalizations non-verbal communication influences pain tolerance in healthy adults.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Participant in good health

Affiliated or entitled participant in a social security scheme

Participant who has received informed information about the study and has co-signed a consent to participate in the study with the investigator.

Disqualifiers

Chronic pain

High blood pressure or poor circulation

Cardiac or vascular disease, or a heart condition (including symptoms of Raynaud's syndrome)

Allergy or hypersensitivity to cold

Trial design

Design model

Single group

Treatments tested in this trial

  • Cold pressor task (CPT)

    Behavioral

    The cold pressor test is among the most common and established methods for studying human reactions to pain and pain tolerance. Participants submerge a hand in cold water (approx. 5°C) and are asked to keep their hand submerged for as long as can (until the sensation is intolerable), up to a maximum of 5 min. The procedure is safe because the hand is removed before adverse effects can occur. The participant will be given a break of 5 min in between trials, and will interchange hands between trials. During this break hand may to be place in warm water (25-35°C) for up to 4 min to normalise hand temperature, which will be measured before and after each trial using a digital thermometer held firmly in the palm of the hand. Each participant will complete no more than three trials (conditions) in a randomised order.

  • Acoustic Recordings

    Behavioral

    During the experiment, the vocalizations produced will be systematically recorded for each participant and an analysis of the acoustic structure of these vocalizations will be carried out.

  • Index measurement NOL™

    Diagnostic test

    Four sensors placed non-invasively on one finger. of the participants will be able to calculate a dozen physiological parameters converts in real time into a pain index called NOL (for Nociception Level Index).

  • Video pupillometry

    Diagnostic test

    This technique is based on the observation of the dilatation of the pupil during the perception of a nociceptive stimulus in test persons.

Treatment groups

104 Participants
are divided into 1 treatment group
Group A: Healthy adult population aged 18 to 60 years.Experimental treatment 4 interventions

Trial outcomes

Primary outcomes

1

Pain tolerance

Delay (in seconds) in removing the hand when testing the Cold Pressor.

Time frame
at inclusion

Secondary outcomes

1

Onset of pain

Participant verbally indicates when he or she begins to feel the sensation of pain (time of onset measured in seconds)

Time frame
at inclusion
2

Pain intensity

Subjective assessment of maximum pain intensity by participants for a given trial. Measured by scale of 0 (no pain) at 100 (extreme pain).

Time frame
at inclusion
3

correlation between NOL index and pupillary diameter

Measurement of the NOL index (index ranging from 0 to 100) and measurement of pupillary diameter (in mm) and its variations in response to nociceptive stimuli by video pupillometry.

Time frame
at inclusion
4

Analysis of Acoustic Recordings

Using a dedicated script in software specialised in acoustic analysis (e.g. PRAAT).

Time frame
at inclusion

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Centre Hospitalier Universitaire de Saint Etienne

Lead sponsor

Laboratoire ENES-CNPS (Université Lyon/Saint Etienne)

Collaborator

Source ClinicalTrials.gov
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