The Effect of Olive Leaf Extract Supplementation on Training-induced Skeletal Muscle Functional and Molecular Adaptations in Healthy Volunteers

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-45
SponsorUniversity of Lausanne

About this trial

The goal of this study is to investigate the effect of combining olive leaf extract supplementation with endurance training (moderate intensity continuous training or sprint interval training). We hypothesize that OLE supplementation during training, as compared to training alone with placebo, will translate into better performance outcomes. More specifically, we hypothesize that the additional benefits of OLE supplementation on performance will be mediated by improved mitochondrial characteristics in skeletal muscle and increased neural activation.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Being between 18 and 45 years old

Being healthy (assessed through the PAR-Q questionnaire).

Being physically active, but not involved in any structured training program

Being available for the study period.

Disqualifiers

If a participant answers positively to any YES/NO question in the PAR-Q health questionnaire. For questions requiring a precision, any positive answer will be reviewed by a medical doctor, who will determine the inclusion/exclusion of the participant.

Having allergy to xylocaine

Being pregnant.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Olive leaf extract

    Dietary supplement

    A capsule containing 250 mg of an olive leaf extract preparation will be swallowed with a glass of water daily for 21 days.

  • Placebo

    Dietary supplement

    A capsule containing 336 mg of cellulose microcrystalline will be swallowed with a glass of water daily for 21 days.

Treatment groups

60 Participants
are divided into 2 treatment groups
Group A: Sprint interval training group (SIT group)Experimental treatment 2 interventions
Group B: Moderate intensity continuous training (MICT group)Experimental treatment 2 interventions

Trial outcomes

Primary outcomes

1

maximal aerobic power

maximal power (in watts) measured during a graded exercise to failure

Time frame
before and after the three-week training period

Secondary outcomes

1

Maximal oxygen uptake

maximal oxygen uptake (ml/min/kg) measured during a graded exercise until failure

Time frame
before and after the three-week training period
2

Submaximal heart rate and power

heart rate and power measured during submaximal cycling exercise

Time frame
before and after the three-week training period
3

Knee extensor neuromuscular function

maximal voluntary contraction force and maximal voluntary activation level

Time frame
before and after the three-week training period

Other outcomes

Sponsors and contacts

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