The Effect of Opioid Free Anesthesia Using Ultrasound-Guided Bilateral Transversus Abdominus Plane Block and Dexmedetomidine Infusion

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age21-65
SponsorTanta University

About this trial

This study aimed to determine the effects of Opioid-free anesthesia using dexmedetomidine and bilateral Transversus abdominis plane block on the quality of recovery, incidence of Opioid-free anesthesia, and post-operative pain and delirium in morbid obese patients undergoing gynecological surgeries.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

50 female patients aged 21-65 years.

Patients with a Body mass index≥ 35 kg/m2

American society of Anesthesiology class II-III.

Undergoing elective gynecological surgeries.

Disqualifiers

Patient refusal.

History of allergy to local anesthetic.

Liver or renal pathology affecting drug elimination.

Mental dysfunction or cognitive disorders.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Opioid Free Anesthesia

    Procedure/Surgery

    patients will receive opioid free anesthesia and bilateral ultrasound guided transversus abdominus plane block.

  • Control group (general anesthesia)

    Procedure/Surgery

    patients will receive conventional general anesthesia

Treatment groups

150 Participants
are divided into 2 treatment groups
Group A: Group I: Opioid Free Anesthesia groupExperimental treatment 1 intervention
Group B: Group II: Control groupPlacebo comparator 1 intervention

Trial outcomes

Primary outcomes

1

quality of recovery on postoperative day

The Quality of Recovery-40 questionnaire scores. The Quality of Recovery-40 questionnaire includes five dimensions of recovery: physical comfort (12 items), emotional state (9 items), physical independence (5 items), psychological support (7 items), and pain (7 items).

Time frame
one day

Secondary outcomes

1

Postoperative pain severity

Postoperative pain severity will be assessed by the numerical rating scale ( 0 no pain while 10 is the maximum pain).

Time frame
24 HOURS

Other outcomes

Sponsors and contacts

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