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The Effect of Pistachio-Rich Breakfast Meals on Cognitive Function in Healthy Older Adults

ConditionCognition
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age65-80
SponsorUniversity of Reading

About this trial

This study aims to investigate the effect of a breakfast meal containing varying serving sizes (doses) of pistachio nuts on cognitive function throughout the course of the day in healthy ageing adults aged 65-80.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

65 - 80 years old

Fruit & veg intake less than or equal to 4 servings per day

Not regularly consuming more than 3 servings of fish per week

Adequate English language and visual & auditory acuity to perform the cognitive tasks

Disqualifiers

Being diagnosed with psychological or psychiatric disorders

ADHD or dyslexia

Any food allergy or intolerance

Use of medications and dietary supplements that may impact study results

Trial design

Design model

Crossover

Treatments tested in this trial

  • 0.5 serving of pistachios

    Dietary supplement

    The equivalent of 0.5 servings (15g) of shelled, roasted pistachio nuts, crushed and mixed into a muesli-based breakfast meal for consumption. Ingredients: 15g pistachio, 35g muesli base, 150g full fat natural yoghurt, 15g unsalted butter (melted), 10g unflavoured whey powder

  • 1 serving of pistachios

    Dietary supplement

    The equivalent of 1 serving (30g) of shelled, roasted pistachio nuts, crushed and mixed into a muesli-based breakfast meal for consumption. Ingredients: 30g pistachio, 35g muesli base, 150g full fat natural yoghurt, 10g unsalted butter (melted), 5g unflavoured whey powder

  • 2 servings of pistachios

    Dietary supplement

    The equivalent of 2 servings (60g) of shelled, roasted pistachio nuts, crushed and mixed into a muesli-based breakfast meal for consumption. Ingredients: 60g pistachios, 25g muesli base, 150g low fat natural yoghurt

  • Placebo

    Dietary supplement

    Macronutrient-matched placebo breakfast meal. Ingredients: 40g muesli base, 150g full fat natural yoghurt, 25g unsalted butter (melted), 15g unflavoured whey powder

Treatment groups

52 Participants
are divided into 4 treatment groups
Group A: PlaceboPlacebo comparator 1 intervention
Group B: 0.5 servings of pistachioExperimental treatment 1 intervention
Group C: 1 serving of pistachioExperimental treatment 1 intervention
Group D: 2 servings of pistachioExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Delayed recall (Rey Auditory Verbal Learning Task)

The RAVLT is a verbal learning task that presents participants with 15 words (list A) 5 times, giving participants one minute after each presentation to recall as many words as they can from the list. After 5 presentations, a new list (list B) is presented and recalled, and finally participants are asked (without hearing list A again) to recall as many words as they can from list A. After a 30 minute period, participants are asked to think back to the task and recall as many words as possible from list A only, providing a measure of delayed recall.

Time frame
Baseline
2

Delayed recall (Rey Auditory Verbal Learning Task)

The RAVLT is a verbal learning task that presents participants with 15 words (list A) 5 times, giving participants one minute after each presentation to recall as many words as they can from the list. After 5 presentations, a new list (list B) is presented and recalled, and finally participants are asked (without hearing list A again) to recall as many words as they can from list A. After a 30 minute period, participants are asked to think back to the task and recall as many words as possible from list A only, providing a measure of delayed recall.

Time frame
2 hours
3

Delayed recall (Rey Auditory Verbal Learning Task)

The RAVLT is a verbal learning task that presents participants with 15 words (list A) 5 times, giving participants one minute after each presentation to recall as many words as they can from the list. After 5 presentations, a new list (list B) is presented and recalled, and finally participants are asked (without hearing list A again) to recall as many words as they can from list A. After a 30 minute period, participants are asked to think back to the task and recall as many words as possible from list A only, providing a measure of delayed recall.

Time frame
4 hours
4

Delayed recall (Rey Auditory Verbal Learning Task)

The RAVLT is a verbal learning task that presents participants with 15 words (list A) 5 times, giving participants one minute after each presentation to recall as many words as they can from the list. After 5 presentations, a new list (list B) is presented and recalled, and finally participants are asked (without hearing list A again) to recall as many words as they can from list A. After a 30 minute period, participants are asked to think back to the task and recall as many words as possible from list A only, providing a measure of delayed recall.

Time frame
6 hours

Secondary outcomes

1

Rate of learning (Rey Auditory Verbal Learning Task)

The RAVLT is a verbal learning task that presents participants with 15 sequential words (list A) 5 times, giving participants one minute after each presentation to recall as many words as they can from the list. Scores are recorded as a percentage of accuracy, and the rate of learning is determined through change in accuracy across the 5 recalls.

Time frame
Baseline
2

Rate of learning (Rey Auditory Verbal Learning Task)

The RAVLT is a verbal learning task that presents participants with 15 sequential words (list A) 5 times, giving participants one minute after each presentation to recall as many words as they can from the list. Scores are recorded as a percentage of accuracy, and the rate of learning is determined through change in accuracy across the 5 recalls.

Time frame
2 hours
3

Rate of learning (Rey Auditory Verbal Learning Task)

The RAVLT is a verbal learning task that presents participants with 15 sequential words (list A) 5 times, giving participants one minute after each presentation to recall as many words as they can from the list. Scores are recorded as a percentage of accuracy, and the rate of learning is determined through change in accuracy across the 5 recalls.

Time frame
4 hours
4

Rate of learning (Rey Auditory Verbal Learning Task)

The RAVLT is a verbal learning task that presents participants with 15 sequential words (list A) 5 times, giving participants one minute after each presentation to recall as many words as they can from the list. Scores are recorded as a percentage of accuracy, and the rate of learning is determined through change in accuracy across the 5 recalls.

Time frame
6 hours

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Reading

Lead sponsor

American Pistachio Growers

Collaborator

Source ClinicalTrials.gov
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