The Effect of Sleep Loss on Emotion Regulation
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-40
SponsorBeth Israel Deaconess Medical Center
About this trial
The study is designed to investigate the impact of three nights of sleep restricted to 4 hours per night, on the processing and regulation of emotional information compared to Insomnia Disorder and control. The investigators will address and attempt to answer two questions.
(i) How do three nights of reduced sleep or a diagnosis of Insomnia Disorder affect the processing and regulation of emotional information compared to typical, undisturbed sleep? (ii) What overlapping and distinct neural mechanisms are engaged and associated with behavioral effects when attempting to process and regulate emotions in a sleep restricted state or with a clinical diagnosis of Insomnia Disorder? This study will investigate sleep's role in emotion processing and regulation. The findings will help further understanding of the role of sleep in healthy emotional functioning.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
willing and able to follow the protocol
willing and able to meet inclusion criteria for fMRI scanning
willing to refrain from alcohol and recreational drugs for the duration of the protocol
normal or corrected to normal vision is required
Disqualifiers
left-handedness or ambidexterity
the use of any drugs that could affect either sleep or cognitive functioning (e.g., prescription sleeping pills or antidepressants)
Trial design
Design model
Parallel
Treatments tested in this trial
Sleep Restriction
BehavioralThree nights of sleep restricted to 4 hours per night.
Treatment groups
90 Participants
are divided into 3 treatment groupsGroup A: Normal SleepNo intervention 0 interventions
Group B: Sleep RestrictionActive comparator 1 intervention
Group C: Patients with Insomnia DisorderNo intervention 0 interventions
Trial outcomes
Primary outcomes
1
Baseline Emotional Regulation Task with Strategy
Baseline behavioral ratings to emotional stimuli with emotion regulation strategies
Time frame
Day 12
Baseline Emotional Regulation Task without Strategy
Baseline behavioral ratings to emotional stimuli without emotion regulation strategies
Time frame
Day 13
Reassessment of the Emotional Regulation Task with Strategy Baseline behavioral ratings to emotional stimuli with or without emotion regulation strategies
Behavioral ratings to emotional stimuli with emotion regulation strategies following normal sleep or sleep restriction
Time frame
one test in a 3-6 day window4
Reassessment of the Emotional Regulation Task without Strategy Baseline behavioral ratings to emotional stimuli with or without emotion regulation strategies
Behavioral ratings to emotional stimuli without emotion regulation strategies following normal sleep or sleep restriction
Time frame
one test in a 3-6 day windowSecondary outcomes
1
Functional Magnetic Resonance Imaging (fMRI)
fMRI measured neural reactivity (blood oxygen-level dependent signal)
Time frame
one test in a 3-6 day windowSponsors and contacts
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Source ClinicalTrials.gov