This study will investigate the effect of providing a daily ketogenic nutritional supplement in the evening for a prolonged time (4 weeks) to induce a mild ketogenic state during the night in healthy elderly (60-80 years), overweight/obese (BMI: 25-35 kg/m2) individuals with low physical activity, on 24h rhythmicity in energy metabolism as compared to a non-ketogenic, isocaloric control.
Aged 60-80 years
Body mass index (BMI) 25-35 kg/m2
Sedentary lifestyle (not more than 2 hours of structured physical activity per week in the past 3 months)
Stable dietary habits (no weight loss or gain > 5 kg in the past 3 months)
Type 2 diabetes
Participants with active congestive heart failure and/or severe renal and or liver insufficiency
Uncontrolled hypertension
Alcohol consumption of >3 servings per day for men and >2 servings per day for women
Crossover
ketogenic nutritional Supplement
Dietary supplementDaily ketogenic nutritional supplement for 4 weeks
non-ketogenic, isocaloric control
Dietary supplementDaily control for 4 weeks
Delta respiratory exchange ratio (from 23:00 till 04:00)
Measured with indirect calorimetry
Skeletal mitochondrial function
Measured in muscle biopsy
Protein and gene markers of skeletal muscle metabolism
Measured in muscle biopsy
Metabolic blood markers
Measured in blood samples
Interstitial ketone levels
Measured with a continuous ketone monitor
Interstitial glucose levels
Measured with a continuous glucose monitor
Click on the lead sponsor to view all of their trials.
