The Effects of Immersive Virtual Reality-Based Exergaming Combined With Transcranial Direct Current Stimulation on Executive Functions in Healthy Older Adults

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age60-70
SponsorBeijing Sport University

About this trial

The goal of this clinical trial is to investigate the acute effects of immersive virtual reality (VR)-based exergaming combined with transcranial direct current stimulation (tDCS) on executive functions in healthy older adults. The main questions it aims to answer are:

* Does VR-based exergaming combined with tDCS improve executive function performance in healthy older adults compared with a control condition? * Do single interventions (tDCS alone or VR-based exergaming alone) improve executive function performance compared with the control condition? * Does the combined intervention produce greater improvements in executive function performance than either intervention alone? Researchers will compare four intervention conditions to evaluate differences in executive function performance following each session.

Participants will:

* Complete four intervention sessions in a randomized crossover sequence, with a washout period of at least 7 days between sessions * Receive the following intervention conditions: * sham-tDCS + VR-video * tDCS + VR-video * sham-tDCS + VR-exergaming * tDCS + VR-exergaming * Complete executive function assessments immediately after each session, including: * the Flanker task for inhibitory control * the more-odd shifting task for cognitive flexibility * the Corsi block-tapping task for working memory

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

None

Disqualifiers

None

Trial design

Design model

Crossover

Treatments tested in this trial

  • transcranial direct current stimulation

    Device

    The anodal electrode is positioned over the left DLPFC (F3), and the cathodal electrode is placed over the right supraorbital area. The transcranial direct current stimulation is applied for 20 min at an intensity of 2 mA, with 15 s ramp-up and 15 s ramp-down.

  • sham transcranial direct current stimulation

    Device

    The anodal electrode is positioned over the left DLPFC (F3), and the cathodal electrode is placed over the right supraorbital area. Sham stimulation is applied in the same locations for 20 min with only 15s ramp-up and 15s ramp-down stimulation to mimic the sensory experience of real stimulation.

  • VR-exergaming

    Behavioral

    For the VR-exergaming condition, participants engage in an interactive rhythm-based fitness game called PowerBeatsVR. It immerses participants in a virtual exercise environment accompanied by dynamic musical beats, with punching and tracking movements. The VR-exergaming consisted of four cycles of 3.5 min, each separated by a 2-min rest interval, for a total duration of 20 min

  • VR-video

    Behavioral

    For the VR-video condition, participants view a mild plant documentary called Journey of Chinese Plants through the same VR headset. VR-video intervention consisted of four cycles of 3.5 min, each separated by a 2-min rest interval, for a total duration of 20 min

Treatment groups

24 Participants
are divided into 4 treatment groups
Group A: Sham tDCS + VR-videoSham comparator 2 interventions
Group B: tDCS + VR-videoExperimental treatment 2 interventions
Group C: Sham tDCS + VR-exergamingExperimental treatment 2 interventions
Group D: tDCS + VR-exergamingExperimental treatment 2 interventions

Trial outcomes

Primary outcomes

1

Reaction time and accuracy of inhibitory control are assessed by the Flanker task.

Time frame
Immediately after the intervention.

Secondary outcomes

1

Reaction time and accuracy of cognitive flexibility are assessed by more odds shifting task.

Time frame
Immediately after the intervention.
2

Scores of working memory are assessed by the Corsi Block-Tapping Task

Time frame
Immediately after the intervention.

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

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