Clinical trials

The goal of this clinical trial is to investigate the acute effects of immersive virtual reality (VR)-based exergaming combined with transcranial direct current stimulation (tDCS) on executive functions in healthy older adults. The main questions it aims to answer are: * Does VR-based exergaming combined with tDCS improve executive function performance in healthy older adults compared with a control condition? * Do single interventions (tDCS alone or VR-based exergaming alone) improve executive function performance compared with the control condition? * Does the combined intervention produce greater improvements in executive function performance than either intervention alone? Researchers will compare four intervention conditions to evaluate differences in executive function performance following each session. Participants will: * Complete four intervention sessions in a randomized crossover sequence, with a washout period of at least 7 days between sessions * Receive the following intervention conditions: * sham-tDCS + VR-video * tDCS + VR-video * sham-tDCS + VR-exergaming * tDCS + VR-exergaming * Complete executive function assessments immediately after each session, including: * the Flanker task for inhibitory control * the more-odd shifting task for cognitive flexibility * the Corsi block-tapping task for working memory

This study aims to investigate the differences in cardiovascular stress response patterns among individuals with various physical activity levels (sedentary controls and different types of athletes). By synchronously monitoring ECG, heart rate, skin sympathetic nerve activity (SKNA), blood pressure, and cardiac output, the study will characterize physiological dynamics during resting, orthostatic challenge, cold pressor stress, and maximal exercise.

What are the requirements for participating in this study? 1. Age 40 to 69, gender unlimited; 2. Insomnia symptoms (difficulty falling asleep, frequent awakenings during sleep, early morning awakening, etc.) occurring three or more times per week for three months or longer (meeting DSM-5 diagnostic criteria for chronic insomnia and International Classification of Sleep Disorders standards); 3.7 points \<ISI baseline score ≤ 21 points (mild to moderate insomnia); 4\. The patient is dissatisfied (option 3) or very dissatisfied (option 4) with their current sleep 5. The incubation period or wake time after falling asleep is more than 30 minutes, and the total sleep time is less than 6.5 hours per day; 6. Willing to follow the exercise prescription and coach's guidance, and cooperate with the exercise intervention for 6 weeks; 7. Being able to maintain consistent lifestyle and sleep patterns throughout the study; 8. Fixed residence and no expectation of moving or traveling within 6 weeks; 9. Sign the informed consent form. You are not eligible to participate in this study if you meet any of the following criteria: 1. Exclude diseases that affect sleep (such as tumors, dementia, obstructive sleep apnea, etc.); 2. Taking medications that may affect sleep (such as steroid hormones, sleeping pills, psychotropic drugs); 3. Abuse of alcohol or drugs in the last 3 months; 4. Liver or kidney dysfunction; 5. History of severe cardiovascular and cerebrovascular diseases; 6. History of mental illness; 7. Expect to work night shifts or travel across time zones or sleep irregularly during the study period; 8. Participated in other intervention clinical trials, including drugs, nutritional preparations and medical devices, within 3 months before the study. What will I experience if I participate in this study? If eligible, participants will be randomly assigned by physicians to one of two study phases: the screening and baseline assessment phase, or the intervention and follow-up phase. The trial consists of three phases, each containing two phases (experimental or control, lasting 1-2 weeks). After enrollment, participants will be randomly assigned to either the Tai Chi intervention group or the walking control group. Throughout the study, participants must cooperate with physicians to complete relevant questionnaires and attend scheduled follow-up visits. What might be the benefits of participating in this study? The research team will cover all expenses for the exercise program. Participants will receive free exercise training, physiological counseling, and standardized assessments throughout the study, including follow-up sessions. Our previous sports medicine research shows that 12 weeks of Tai Chi therapy can significantly improve insomnia symptoms. What are the risks of participating in this study? Participants who have not exercised for a long time may have adverse reactions such as muscle pain and joint pain caused by exercise in the early stage of the experiment or during the study, or even lead to the termination of the experiment. Is participation in this study mandatory? No, participation in this study is entirely voluntary. Can I quit the study midway? Yes, you can opt out at any time, and this will not affect your legal right to continue regular checkups or treatments. Are my personal information confidential? Your personal privacy will be strictly protected within the bounds of applicable laws. Monitoring officers, auditors, ethics committees, and management authorities shall be permitted to directly access participants 'original medical records to verify clinical trial procedures and data, provided such access does not violate applicable laws and regulations or infringe upon participants' privacy. Throughout the study, participants have the right to withdraw from the research at any time without facing discrimination, retaliation, or disruption of medical services. All personal information collected during the study remains confidential. Participants are entitled to consult our physicians with any questions at any time. Patient Statement (Please tick in parentheses): 1. I have reviewed the relevant research materials for this study (version v1.0)···········□ 2. I have carefully considered the matter, consulted a doctor about the relevant issues, and received satisfactory answers······□ 3. I understand that participation in this study is voluntary and that I have the right to withdraw from this study at any time without any reason without affecting my medical treatment and rights·····□ 4. I understand that my relevant materials will be reviewed by the research unit or members of the strict management agency in this study. I agree to the above personnel reviewing and using my relevant materials. ·······················□ 5. I agree to participate in this study·····························□

The purpose of the study is to investigate the effects of short-term braking on the motor learning and fine motor skills of healthy adults, and to analyze whether transcranial direct current stimulation can alleviate the effects of braking on motor learning and fine motor skills.

This study aimed to investigate whether six weeks of tDCS combined with lower-limb resistance training could enhance motor learning in healthy young adults and examined the persistence of any observed benefits.

The goal of this clinical trial is to investigate the effects of different intensities of transcranial direct current stimulationover primary motor cortex on motor learning in healthy adults. The main question it aims to answer is: Which intensity of tDCS can best improve motor learning? Researchers will compare 1 mA, 2 mA, and 3 mA tDCS to sham tDCS to see which intensity of tDCS is most effective in improving the ability of motor learning. Participants will be randomly divided into four groups and receive 4 different intensities of tDCS(1 mA, 2 mA, 3 mA and sham tDCS),and will be blinded to the type of tDCS they received. We hypothesized that anodal tDCS at 2 mA would produce the most substantial improvement in motor learning.

Exploring the efficacy and acceptability of exercise snacks (ES) and sprint interval training (SIT) could provide time-efficient, low-barrier alternatives for individuals, especially those who, due to 'lack of time, environment, and equipment,' struggle to meet traditional physical activity recommendations. This research aims to investigate the effects of ES and SIT, of equal exercise volume, on overweight adults.