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The Effects of Low-Flow and Normal-Flow Sevoflurane Anesthesia on Frontal QRS-T Angle and TP-e Interval

ConditionsCardiac ArrhythmiaAnesthesia
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorIstanbul University

About this trial

Laparoscopic cholecystectomy procedures involve pneumoperitoneum and volatile anesthetics, both of which can significantly influence cardiovascular physiology and autonomic balance. While volatile anesthetics are known to affect myocardial repolarization, the specific impact of Low-Flow Anesthesia (LFA)-a cost-effective and environmentally friendly technique-on these cardiac markers remains under-researched.

This prospective observational study aims to compare the effects of low-flow versus normal-flow sevoflurane anesthesia on two critical non-invasive biomarkers of ventricular repolarization: the Frontal QRS-T angle and the Tp-e interval. These parameters are essential for predicting electrical instability and the risk of malignant arrhythmias. The study will evaluate a total of 128 patients to determine whether different fresh gas flow rates lead to significant changes in cardiac electrophysiological stability during the perioperative and early postoperative periods.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Patients aged 18 years and older.

Patients scheduled for elective or semi-elective laparoscopic cholecystectomy.

Patients who provide written voluntary informed consent.

Patients with a predicted surgical duration between 60 and 180 minutes.

Disqualifiers

Patients with heart failure.

Patients with valvular heart disease or pathology.

Patients with hemodynamic instability.

Patients requiring blood transfusion.

Trial population

The study population consists of adult patients (aged 18 years and older) scheduled for elective or semi-elective laparoscopic cholecystectomy at a tertiary care training and research hospital.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • low flow anesthesia

    Procedure/Surgery

    Fresh Gas Flow (FGF) reduced to 0.5 L/min after the target concentration (MACage +1) is reached.

Treatment groups

128 Participants
are divided into 2 treatment groups
Group A: Low-Flow Group (LFG)1 intervention
Group B: Normal-Flow Group (NFG)0 interventions

Trial outcomes

Primary outcomes

1

Frontal QRS-T angle

electrocardiogram

Time frame
Pre-operative period, 5 minutes after induction, 15 minutes after induction, post operative 15th minute
2

Tp-e interval

electrocardiogram

Time frame
Pre-operative period, 5 minutes after induction, 15 minutes after induction, post-operative 15th minute

Secondary outcomes

1

blood pressure

Non-invasive blood pressure (NIBP) monitor

Time frame
during peri-operative period
2

heart rate

electrocardiogram

Time frame
during peri-operative period
3

Tp-e/QT ratio

electrocardiogram

Time frame
Pre-operative period, 5 minutes after induction, 15 minutes after induction, post-operative 15th minute
4

Total amount of volatile anesthetic consumed

Mindray anesthesia machine

Time frame
end of operation

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Istanbul University

Lead sponsor

Haseki Training and Research Hospital

Sponsor institution

Source ClinicalTrials.gov

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