The Effects of Oxytocin on Fairness Perception and Related Prosocial Behaviors

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-35
SponsorUniversity of Electronic Science and Technology of China

About this trial

This study aims to investigate the modulation of intranasally administered oxytocin (24 IU) on human fairness perception and related prosocial behaviors.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Healthy subjects without past or current psychiatric or neurological disorders.

Disqualifiers

History of head injury; pregnant, menstruating, taking oral contraceptives; medical or psychiatric illness.

The presence of metal in the body or claustrophobia.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Oxytocin nasal spray

    Drug

    intranasal administration of oxytocin (24IU)

  • Placebo

    Drug

    intranasal administration of placebo (24IU)

Treatment groups

80 Participants
are divided into 2 treatment groups
Group A: oxytocin groupExperimental treatment 1 intervention
Group B: placebo groupPlacebo comparator 1 intervention

Trial outcomes

Primary outcomes

1

Fairness rating scores

Participants are asked to rate their perceived levels of fairness on a 9-point Likert scale (1 = highly fair, 9 = highly unfair) to the computer's allocation in each trial.

Time frame
1 hour
2

Anticipated guilt rating scores

Participants are asked to rate the anticipated guilt they would feel if they accepted the allocation given by the computer in each trial. Ratings were conducted on a 9-point Likert scale (1 = not at all, 9 = highly guilty).

Time frame
1 hour
3

The binary decision to the initial allocation

Participants are asked to makde decisions of accepting or rejecting the allocation provided by the computer in each trial.

Time frame
1 hour
4

Brain activity patterns

Brain activity patterns in response to the outcome of the allocation given by computer and the binary decision. We will examine these brain response patterns via both the conventional univariate analysis and the machine learning-based multivariate pattern analysis (MVPA) approaches.

Time frame
1 hour

Secondary outcomes

1

Inequity aversion parameters derived from the Fehr-Schmidt model

Inequity aversion parameters derived from the Fehr-Schmidt model are used to elucidate whether OT would modulate inequity aversion. This model-based analysis was conducted based on choices using hierarchical Bayesian modeling. In the Fehr-Schmidt model, the subjective value of a given allocationis determined by one's own and the other's allocation using the following formula: SV(Mself, Mother) = Mself - βmax{ Mself - Mother, 0}, Mself ≠ Mother where Mself is one's payoff and Mother is the other's payoff. Parameter β represents the weight assigned to inequity. Higher parameter values indicate a stronger degree of inequity aversion in participants.

Time frame
1 hour

Other outcomes

Sponsors and contacts

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