The Impact of LBBAP vs RVP on the Incidence of New-onset Atrial Fibrillation in Patients With Atrioventricular Block

ConditionsLeft Bundle Branch Area Pacing Right Ventricular Pacing Atrioventricular Block Atrial Fibrillation

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18-85

SponsorPeking Union Medical College Hospital

About this trial

This is a single-center, randomized controlled study. The aim of this study is to compare the impact of left bundle branch area pacing versus traditional right ventricular pacing on the incidence of atrial fibrillation in patients with atrioventricular block.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Adult patients aged 18-85;

AV block patients with ventricular pacing indications and the expected rate of ventricular pacing(VP)> 40%, including (a) third-degree AV block; (b) second degree AV block (type II); (c) intermittent advanced AV block with expected VP>40%; (d) symptomatic first degree AV block and PR interval on ECG > 300ms;

Signed informed consent;

Disqualifiers

Baseline echocardiographic assessment of patients with impaired LV function (LVEF<50%);

Patients with the history of atrial fibrillation;

Having difficulties in follow-up: Those who cannot accept 2-year follow-up on time due to physical condition or other reasons;

Pacemaker replacement without new implanted ventricular electrodes;

Trial design

Design model

Parallel

Treatments tested in this trial

left bundle branch area pacing
Procedure/Surgery
Left bundle branch area pacing(LBBAP) is a novel physiological pacing form for ventricular pacing. In patients received LBBAP, the pacing lead will be placed at left bundle branch area to achieve narrow paced QRS duration.
right ventricular pacing
Procedure/Surgery
Right ventricular pacing is the traditional pacing modality for ventricular pacing. The pacing lead was placed in the apex or septum of right ventricle.

Treatment groups

530 Participants

are divided into 2 treatment groups

Group A: left bundle branch area pacingExperimental treatment 1 intervention

Group B: right ventricular pacingActive comparator 1 intervention