About this trial
The goal of this observational study is to learn about the effects of different types of anemia on HbA1c test results in non-diabetic adults who have anemia but do not have diabetes. The main question it aims to answer is:
\- Do different types of anemia (iron deficiency, vitamin B12/folate deficiency, thalassemia, and anemia of chronic illness) cause HbA1c levels to be falsely high or low in people without diabetes?
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Fasting plasma glucose < 126 mg/dL and/or
HbA1c < 6.5%, with no prior diagnosis of diabetes mellitus.
Hemoglobin < 13 g/dL in males
Hemoglobin < 12 g/dL in female
Disqualifiers
Known cases of diabetes mellitus or prediabetes.
Recent blood transfusion within the last 3 months.
Use of medications known to affect HbA1c levels
Acute illness or infection at the time of enrollment.
Trial population
Non-diabetic adult individuals attending the outpatient clinics and/or admitted to the internal medicine departments of Sohag University Hospital . Participants will be classified into different groups based on the presence and type of anemia (e.g., iron deficiency anemia, vitamin B12 deficiency anemia, folate deficiency anemia, anemia of chronic disease), in addition to a control group of non-anemic individuals.
Trial design
Cohort
Cross-sectional
Treatments tested in this trial
Not listed
Trial groups
Trial outcomes
Primary outcomes
Mean HbA1c Level
Comparison of mean glycosylated hemoglobin (HbA1c) levels, measured as a percentage (%), between non-diabetic adults diagnosed with specific types of anemia (iron deficiency anemia, vitamin B12 deficiency anemia, folate deficiency anemia, and anemia of chronic disease) and a non-anemic control group.
Secondary outcomes
Correlation Between HbA1c and Hemoglobin Concentration
Evaluation of the correlation between glycosylated hemoglobin (HbA1c) levels, measured as a percentage (%), and hemoglobin (Hb) concentration, measured in grams per deciliter (g/dL), across all study participants (including both anemic subgroups and non-anemic controls).
Correlation Between HbA1c and Mean Corpuscular Volume (MCV)
Evaluation of the correlation between glycosylated hemoglobin (HbA1c) levels and mean corpuscular volume (MCV). HbA1c is measured as a percentage (%). MCV is measured in femtoliters (fL).
Correlation Between HbA1c and Mean Corpuscular Hemoglobin (MCH)
Evaluation of the correlation between glycosylated hemoglobin (HbA1c) levels and mean corpuscular hemoglobin (MCH). HbA1c is measured as a percentage (%). MCH is measured in picograms (pg).
Correlation Between HbA1c and Mean Corpuscular Hemoglobin Concentration (MCHC)
Evaluation of the correlation between glycosylated hemoglobin (HbA1c) levels and mean corpuscular hemoglobin concentration (MCHC). HbA1c is measured as a percentage (%). MCHC is measured in grams per deciliter (g/dL).
Sponsors and contacts
Click on the lead sponsor to view all of their trials.
This trial is not recruiting at the moment. You can still explore other options: