The aim of the proposed study is to investigate the effect of increased plasma lactate concentrations on the heart and brain's metabolism of other energy sources, primarily glucose in the brain and glucose and FFA in the heart.
The investigator hypothesize that:
* An acute increase in lactate plasma concentration will decrease cerebral glucose uptake and increase cerebral blood flow * An acute increase in lactate plasma concentration will decrease palmitate and glucose uptake in the myocardium, and increase myocardial perfusion
Age 55-75 years
Male or postmenopausal female
BMI 20-35 kg/m2
Signed informed consent form
Clinically significant heart, lung, kidney, kidney, liver, endocrine or malignant disease basedon information obtained during an initial screening visit as well as blood samples and an ECG.
Blood donation within the last 3 months
Smoking
Alcohol- or substance abuse
Crossover
Sodium Lactate Solution
Other interventionInfusion of sodium-lactate solution
Saline infusion (placebo)
Other interventionNaCl solution
Cerebral glucose uptake
Cerebral glucose uptake (\[18F\]FDG PET scan) under basal and hyperinsulinemic- euglycemic conditions (clamp conditions).
Cerebral blood flow
Cerebral blood flow (\[15O\]H2O PET scan)
Myocardial perfusion
Myocardial perfusion (\[15O\]H2O PET scan)
Myocardial glucose uptake
Myocardial glucose uptake (\[18F\]FDG PET scan)
Myocardial FFA uptake and oxidation
Myocardial FFA uptake and oxidation (\[11C\]Palmitate PET scan)
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University of Aarhus
Lead sponsor
Aarhus University Hospital
Collaborator
This trial is not recruiting at the moment. You can still explore other options:
