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The Physiological Effect of RCexp on Ventilation/Perfusion Distribution

ConditionsAcute Respiratory Distress SyndromeMechanical Ventilation
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age19+
SponsorSoutheast University, China

About this trial

With the exception of setting the positive end-expiratory pressure (PEEP), the expiratory phase is commonly overlooked during MV. The expiratory time constant (RCexp) plays an important role in understanding the mechanical properties of the respiratory system in patients receiving mechanical ventilation. However, it is unclear that the effect of expiratory time constant on the ventilation and perfusion distribution.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

None

Disqualifiers

age <18 years old

patient undergoing legal protection

contra-indications to EIT (e. g. severe chest trauma or wounds)

pneumothorax

Trial population

1. Intubated patients with moderate and severe ARDS (Berlin definition, PaO2/FiO2 ≤200 mmHg at PEEP 5 cmH2O) 2. undergoing deep sedation on controlled mechanical ventilation within72 hours after ARDS onset

Trial design

Design model

Case-crossover

Time perspective

Prospective

Treatments tested in this trial

  • RCexp

    Other intervention

    patients received different RCexp

Treatment groups

60 Participants
are divided into 1 treatment group
Group A: mechanically ventilated patients with ARDS1 intervention

Trial outcomes

Primary outcomes

1

Difference in ventilation/perfusion mismatch

ventilation/perfusion mismatch is measured by EIT

Time frame
4 hours

Secondary outcomes

1

Difference in dead space

dead space is measured by EIT

Time frame
4 hours
2

Difference in shunt

shunt is measured by EIT

Time frame
4 hours

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Southeast University, China

Lead sponsor

Source ClinicalTrials.gov
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