The Prevalence and the Pathophysiological Role of Non-Helicobacter Pylori Helicobacter Spp. in Well-defined Gastric Diseases and (Pre-) Malignancies

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversiteit Antwerpen

About this trial

The goal of this clinical trial is to discover the prevalence of NHPH bacteria (Non-Helicobacter pylori Helicobacter species) in patients with one of the following conditions:

1. Functional dyspepsia following the Rome IV criteria 2. Active chronic gastritis, non-H. pylori induced atrophic gastritis, intestinal metaplasia and non-H.pylori gastric dysplasia 3. Gastric cancer, including siewert type 2 and 3 esophagastric junction cancers In addition, patients undergoing bariatric surgery are included as a control group. This study will be conducted using a prospective analysis in the three targeted study populations. Biopsy specimens routinely taken during the medical procedure or via the resected material in patients belonging to the target groups will be used.

Exclusion criteria:

* Patients with a history of H. pylori infection diagnosed by serology, on gastric biopsy, by breath test or on antigen test in stool samples. * Pregnancy. * Underage patients (\< 18 years).

Eligibility criteria

Qualifiers

part of the study population

Disqualifiers

Patients with a history of H. pylori infection diagnosed by serology, on gastric biopsy, by breath test or on antigen test in stool samples.

Pregnancy.

Underage patients (< 18 years).

Trial design

Treatments tested in this trial

  • Not listed

Trial groups

150 Participants
are grouped into 4 trial groups

Sponsors and collaborators

Universiteit Antwerpen

Lead sponsor

University Hospital, Antwerp

Collaborator

Algemeen Ziekenhuis Maria Middelares

Collaborator

General Hospital Groeninge

Collaborator