Health TrialsbyHealthPanel

The Relation of Albumin/Globulin Ratio and Platelet/Albumin Ratio to Lupus Nephritis

ConditionsLupus Nephritis (LN)SLE - Systemic Lupus ErythematosusBiomarkers
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorAssiut University

About this trial

Albumin/globulin ratio and platelet/albumin ratio as a predictive non-invasive biomarker for lupus nephritis (LN) presence and severity

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients aged 18 years or older diagnosed as SLE according to 2019 ACR/EULAR classification criteria and with lupus nephritis (LN) according to the ACR criteria.

Patients with available baseline laboratory investigations and renal biopsy.

Disqualifiers

Patients with chronic liver disease, hematological disorders, or malignancies affecting albumin/globulin ratio or platelet counts.

Patients on nephrotoxic medications not related to SLE management.

Recent infections or acute inflammatory conditions.

Trial population

Aged ≥18 years. * SLE patients fulfilling the SLE International Collaborating Clinics (SLICC) - ----classification criteria and matched controls. * Patients cooperative and can answer questions. * Patients who are able and willing to give written informed consent.

Trial design

Design model

Cohort

Time perspective

Cross-sectional

Treatments tested in this trial

Not listed

Trial groups

No trial groups listed

Trial outcomes

Primary outcomes

1

Association of Albumin/Globulin (A/G) and Platelet/ Albumin (P/A) ratios with the presence of lupus nephritis

unit of measurments : ratios (no units )

Time frame
baseline
2

Compare the Albumin/Globulin (A/G) and Platelet/Albumin (P/A) ratios between different classes of lupus nephritis

unite of measurments : ratios (no units )

Time frame
baseline

Secondary outcomes

1

• Correlation of A/G and P/A ratios with lupus nephritis class, 24-hour urine protein or urine protein/creatinine ratio, Serum creatinine and eGFR.

Time frame
baseline
2

• Predictive value of A/G and P/A ratios for renal involvement: Using logistic regression or ROC curve analysis to assess whether these ratios can predict the presence of nephritis.

Time frame
baseline

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Assiut University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: